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Table 5 Significant biological processes and pathways of a more toxic response

From: Discernment of possible mechanisms of hepatotoxicity via biological processes over-represented by co-expressed genes

Identifier

Term

p-value

Up-regulated

  

GO:0002274

myeloid leukocyte activation

3.04E-05

GO:0002444

myeloid leukocyte mediated immunity

7.08E-05

GO:0045321

leukocyte activation

1.95E-04

GO:0002349

histamine production during acute inflammatory response

1.21E-03

GO:0001821

histamine secretion

1.21E-03

GO:0012502

induction of programmed cell death

1.54E-03

GO:0002532

production of molecular mediator of acute inflammatory response

2.39E-03

GO:0043067

regulation of programmed cell death

2.40E-03

GO:0051052

regulation of DNA metabolic process

2.95E-03

GO:0032496

response to lipopolysaccharide

3.11E-03

GO:0006626

protein targeting to mitochondrion

4.51E-03

GO:0019221

cytokine and chemokine mediated signaling pathway

5.78E-03

GO:0002443

leukocyte mediated immunity

6.19E-03

GO:0006935

chemotaxis

6.58E-03

GO:0006952

defense response

6.91E-03

GO:0043068

positive regulation of programmed cell death

9.83E-03

rno04670

Leukocyte transendothelial migration

2.50E-04

rno00450

Selenoamino acid metabolism

3.71E-02

rno04650

Natural killer cell mediated cytotoxicity

4.56E-02

rno00010

Glycolysis/Gluconeogenesis

7.89E-02

Down-regulated

  

GO:0006091

generation of precursor metabolites and energy

2.16E-10

GO:0008610

lipid biosynthetic process

2.28E-09

GO:0006695

cholesterol biosynthetic process

6.87E-07

GO:0008203

cholesterol metabolic process

3.62E-06

GO:0006631

fatty acid metabolic process

6.22E-06

GO:0044262

cellular carbohydrate metabolic process

4.21E-04

GO:0042221

response to chemical stimulus

7.85E-04

GO:0005975

carbohydrate metabolic process

8.15E-04

GO:0009896

positive regulation of catabolic process

1.05E-03

GO:0050818

regulation of coagulation

1.40E-03

GO:0007596

blood coagulation

2.68E-03

GO:0045819

positive regulation of glycogen catabolic process

3.03E-03

GO:0007599

hemostasis

3.71E-03

GO:0042493

response to drug

5.78E-03

GO:0002526

acute inflammatory response

8.75E-03

GO:0050819

negative regulation of coagulation

9.20E-03

rno01040

Polyunsaturated fatty acid biosynthesis

2.17E-05

rno04610

Complement and coagulation cascades

3.70E-05

rno00960

Alkaloid biosynthesis II

1.28E-02

rno03320

PPAR signaling pathway

2.31E-02

rno00071

Fatty acid metabolism

2.52E-02