Table 1 Genes affected by maternal diabetes classified by cellular function. see Additional file 1
From: Maternal diabetes alters transcriptional programs in the developing embryo
Functional category | # of genes | % of total | Gene Symbol |
|---|---|---|---|
Transcription factors | 15 | 12 | Bcl11a, Cited4, Creb1, Crsp2, Hif1a, Klf9, Lin28, Nsd1, Rb1cc1, Rnf14, Zfa, Zfp60, Zfp294, Zfp385, 2610020O08Rik |
DNA-binding/chromatin | 8 | 6 | Atrx, Baz1b, Exod1, Hist1h2bc, Hmga1, Msl31, Setdb1, Top2b |
Signal transduction | 15 | 12 | Ap1g1, Arid4b, Gad1, Grb10, Mapk10, Phip, Pik3c2a, Pkia, Ptp4a3, Ptprs, Rabgap1, Rp2h, Stam2, Ywhag, Zcsl3 |
Cell surface, incl. receptors | 13 | 10 | Agtr2, Aplp2, Cxadr, Efnb2, Epha3, Ghr, Gpr65, Il6st, Itgav, Pdgfra, Ptprk, Sema3a, Tgfbr1 |
Extracellular matrix/adhesion | 9 | 7 | Adam10, Ctse, Hs6st2, Ndst1, Ogt, Pcdh18, Pxn, Sel1h, Twsg1 |
Cytoskeleton/microtubules | 10 | 8 | Dcx, Dnm1l, Epb4.1l2, Gmfb, Kif11, Mtap2, Sncg, Tubb2b, Tubb2c, Vcl |
RNA-binding | 7 | 6 | Arl5a, Dcp1a, Pabpc1, Rnpc2, Rod1, Sfrs2, Syncrip |
Transporter/channels | 9 | 7 | Abcb7, Aqr, Cacna2d1, Mbtps1, Slc2a1, Slc16a3, Slc25a22, Stx17, Tm9sf3 |
Metabolism/enzymes | 6 | 5 | Aldh18a1, Blvrb, Gmpr, Pfkl, Tnks2, Upp1 |
Lipid metabolism | 6 | 5 | Etnk1, Hdlbp, Scd2, Sgpl1, Sptlc1, Stom |
Metal-ion homeostasis | 3 | 2 | LOC669660, Mt2, Tfrc |
Protein catabolism | 9 | 7 | Arih2, Nedd4, Supt16h, Usp7, Usp12, Eif3s10, Gopc, Lin7c, Vps35 |
Cell cycle/apoptosis | 3 | 2 | Api5, Birc4, Kras |
Other | 6 | 5 | Dysf, Ivns1abp, Pelp1, Plekha5, Trim2, Trim44 |
Unknown | 7 | 6 | Heatr1, BC067396, 1300007C21Rik, 6330503C03Rik, 6330527O06Rik, 6330578E17Rik, LOC640370 |
total | 126 | 100 | Â |