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Table 4 Wnt-pathway genes affected by maternal diabetes.

From: Maternal diabetes alters transcriptional programs in the developing embryo

 

Control

 

Exp. II

     
 

Mean

(+/-SD)

Mean

(+/-SD)

p-value

fold-change

Gene Symbol

Gene Title

1450007_at

602

(± 141)

76

(± 23)

0.0031

-7.93

1500003O03Rik

similar to EF-hand Ca2+ binding protein p22

1450056_at

423

(± 43)

103

(± 42)

0.0008

-4.12

Apc

adenomatosis polyposis coli

1455231_s_at

326

(± 71)

97

(± 3)

0.0052

-3.36

Apc2

adenomatosis polyposis coli 2

1426966_at

1257

(± 52)

530

(± 52)

6.6-5

-2.37

Axin1

axin 1

1444031_at

17

(± 5)

47

(± 6)

0.0028

2.80

Camk2d

calcium/calmodulin-dependent protein kinase II, delta

1417176_at

3354

(± 833)

1102

(± 385)

0.0132

-3.04

Csnk1e

casein kinase 1, epsilon

1422887_a_at

3473

(± 351)

1625

(± 222)

0.0015

-2.14

Ctbp2

C-terminal binding protein 2

1430533_a_at

3643

(± 841)

333

(± 352)

0.0033

-10.95

Ctnnb1

beta-catenin

1458662_at

167

(± 35)

75

(± 18)

0.0152

-2.23

Daam1

dishevelled associated activator of morphogenesis 1

1450978_at

965

(± 42)

430

(± 40)

9.0-5

-2.24

Dvl1

dishevelled homolog 1

1417207_at

993

(± 91)

327

(± 46)

0.0004

-3.04

Dvl2

dishevelled homolog 2

1455220_at

181

(± 12)

76

(± 12)

0.0004

-2.39

Frat2

frequently rearranged in advanced T-cell lymphomas 2

1437284_at

2115

(± 66)

965

(± 32)

1.1-5

-2.19

Fzd1

frizzled homolog 1

1418532_at

1720

(± 389)

551

(± 193)

0.0096

-3.12

Fzd2

frizzled homolog 2

1450044_at

2329

(± 163)

884

(± 174)

0.0005

-2.63

Fzd7

frizzled homolog 7

1423348_at

419

(± 33)

188

(± 35)

0.0011

-2.23

Fzd8

frizzled homolog 8

1427529_at

136

(± 24)

57

(± 21)

0.0125

-2.40

Fzd9

frizzled homolog 9

1455689_at

485

(± 124)

204

(± 22)

0.0182

-2.37

Fzd10

frizzled homolog 10

1451020_at

434

(± 144)

156

(± 28)

0.0303

-2.79

Gsk3b

glycogen synthase kinase 3 beta

1417409_at

1585

(± 117)

664

(± 114)

0.0006

-2.39

Jun

Jun oncogene

1425795_a_at

1069

(± 122)

423

(± 92)

0.0018

-2.53

Map3k7

mitogen activated protein kinase kinase kinase 7

1452497_a_at

192

(± 85)

39

(± 4)

0.0353

-4.97

Nfatc3

nuclear factor of activated T-cells, calcineurin-dependent 3

1423379_at

497

(± 87)

81

(± 9)

0.0012

-6.17

Nfatc4

nuclear factor of activated T-cells, calcineurin-dependent 4

1419466_at

353

(± 31)

166

(± 5)

0.0005

-2.13

Nkd2

naked cuticle homolog 2

1448661_at

385

(± 42)

189

(± 47)

0.0057

-2.04

Plcb3

phospholipase C, beta 3

1439797_at

306

(± 67)

100

(± 27)

0.0078

-3.05

Ppard

peroxisome proliferator activator receptor delta

1426401_at

1094

(± 85)

525

(± 41)

0.0005

-2.08

Ppp3ca

protein phosphatase 3, catalytic subunit, alpha isoform

1427468_at

1103

(± 170)

207

(± 169)

0.0029

-5.32

Ppp3cb

protein phosphatase 3, catalytic subunit, beta isoform

1450368_a_at

186

(± 53)

83

(± 16)

0.0321

-2.23

Ppp3r1

protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)

1452878_at

366

(± 35)

172

(± 32)

0.0021

-2.13

Prkce

protein kinase C, epsilon

1448695_at

242

(± 84)

70

(± 28)

0.0284

-3.44

Prkci

protein kinase C, iota

1424287_at

190

(± 55)

34

(± 12)

0.0084

-5.53

Prkx

protein kinase, X-linked

1451358_a_at

2310

(± 218)

1154

(± 250)

0.0038

-2.00

Racgap1

Rac GTPase-activating protein 1

1416577_a_at

5908

(± 412)

11936

(± 1884)

0.0056

2.02

Rbx1

ring-box 1

1423444_at

1347

(± 351)

657

(± 105)

0.0311

-2.05

Rock1

Rho-associated coiled-coil containing protein kinase 1

1425465_a_at

611

(± 128)

194

(± 73)

0.0080

-3.15

Senp2

SUMO/sentrin specific peptidase 2

1416594_at

722

(± 105)

300

(± 44)

0.0030

-2.41

Sfrp1

secreted frizzled-related protein 1

1422485_at

2828

(± 354)

1189

(± 425)

0.0068

-2.38

Smad4

MAD homolog 4

1434644_at

780

(± 274)

29

(± 15)

0.0090

-27.22

Tbl1x

transducin (beta)-like 1 X-linked

1429427_s_at

221

(± 5)

460

(± 97)

0.0132

2.08

Tcf7l2

transcription factor 7-like 2, T-cell specific, HMG-box

1455592_at

1336

(± 506)

306

(± 101)

0.0258

-4.37

Vangl2

vang-like 2 (van Gogh homolog)

1448818_at

212

(± 68)

82

(± 16)

0.0326

-2.60

Wnt5a

wingless-related MMTV integration site 5A

1420892_at

645

(± 120)

213

(± 15)

0.0035

-3.03

Wnt7b

wingless-related MMTV integration site 7B

  1. Components of the Wnt pathway were identified according to KEGG and GenMAPP annotation. Affymetrix probe ID numbers are given for representative probe sets. Means of signal intensities and standard deviations were rounded the next full figure; p-values were rounded to the fourth digit after the period except where otherwise indicated; fold-change values were rounded to the second digit after the period. Negative fold-change values indicate reduced expression level in diabetes-exposed embryos.