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Table 4 Wnt-pathway genes affected by maternal diabetes.

From: Maternal diabetes alters transcriptional programs in the developing embryo

  Control   Exp. II      
  Mean (+/-SD) Mean (+/-SD) p-value fold-change Gene Symbol Gene Title
1450007_at 602 (± 141) 76 (± 23) 0.0031 -7.93 1500003O03Rik similar to EF-hand Ca2+ binding protein p22
1450056_at 423 (± 43) 103 (± 42) 0.0008 -4.12 Apc adenomatosis polyposis coli
1455231_s_at 326 (± 71) 97 (± 3) 0.0052 -3.36 Apc2 adenomatosis polyposis coli 2
1426966_at 1257 (± 52) 530 (± 52) 6.6-5 -2.37 Axin1 axin 1
1444031_at 17 (± 5) 47 (± 6) 0.0028 2.80 Camk2d calcium/calmodulin-dependent protein kinase II, delta
1417176_at 3354 (± 833) 1102 (± 385) 0.0132 -3.04 Csnk1e casein kinase 1, epsilon
1422887_a_at 3473 (± 351) 1625 (± 222) 0.0015 -2.14 Ctbp2 C-terminal binding protein 2
1430533_a_at 3643 (± 841) 333 (± 352) 0.0033 -10.95 Ctnnb1 beta-catenin
1458662_at 167 (± 35) 75 (± 18) 0.0152 -2.23 Daam1 dishevelled associated activator of morphogenesis 1
1450978_at 965 (± 42) 430 (± 40) 9.0-5 -2.24 Dvl1 dishevelled homolog 1
1417207_at 993 (± 91) 327 (± 46) 0.0004 -3.04 Dvl2 dishevelled homolog 2
1455220_at 181 (± 12) 76 (± 12) 0.0004 -2.39 Frat2 frequently rearranged in advanced T-cell lymphomas 2
1437284_at 2115 (± 66) 965 (± 32) 1.1-5 -2.19 Fzd1 frizzled homolog 1
1418532_at 1720 (± 389) 551 (± 193) 0.0096 -3.12 Fzd2 frizzled homolog 2
1450044_at 2329 (± 163) 884 (± 174) 0.0005 -2.63 Fzd7 frizzled homolog 7
1423348_at 419 (± 33) 188 (± 35) 0.0011 -2.23 Fzd8 frizzled homolog 8
1427529_at 136 (± 24) 57 (± 21) 0.0125 -2.40 Fzd9 frizzled homolog 9
1455689_at 485 (± 124) 204 (± 22) 0.0182 -2.37 Fzd10 frizzled homolog 10
1451020_at 434 (± 144) 156 (± 28) 0.0303 -2.79 Gsk3b glycogen synthase kinase 3 beta
1417409_at 1585 (± 117) 664 (± 114) 0.0006 -2.39 Jun Jun oncogene
1425795_a_at 1069 (± 122) 423 (± 92) 0.0018 -2.53 Map3k7 mitogen activated protein kinase kinase kinase 7
1452497_a_at 192 (± 85) 39 (± 4) 0.0353 -4.97 Nfatc3 nuclear factor of activated T-cells, calcineurin-dependent 3
1423379_at 497 (± 87) 81 (± 9) 0.0012 -6.17 Nfatc4 nuclear factor of activated T-cells, calcineurin-dependent 4
1419466_at 353 (± 31) 166 (± 5) 0.0005 -2.13 Nkd2 naked cuticle homolog 2
1448661_at 385 (± 42) 189 (± 47) 0.0057 -2.04 Plcb3 phospholipase C, beta 3
1439797_at 306 (± 67) 100 (± 27) 0.0078 -3.05 Ppard peroxisome proliferator activator receptor delta
1426401_at 1094 (± 85) 525 (± 41) 0.0005 -2.08 Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform
1427468_at 1103 (± 170) 207 (± 169) 0.0029 -5.32 Ppp3cb protein phosphatase 3, catalytic subunit, beta isoform
1450368_a_at 186 (± 53) 83 (± 16) 0.0321 -2.23 Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
1452878_at 366 (± 35) 172 (± 32) 0.0021 -2.13 Prkce protein kinase C, epsilon
1448695_at 242 (± 84) 70 (± 28) 0.0284 -3.44 Prkci protein kinase C, iota
1424287_at 190 (± 55) 34 (± 12) 0.0084 -5.53 Prkx protein kinase, X-linked
1451358_a_at 2310 (± 218) 1154 (± 250) 0.0038 -2.00 Racgap1 Rac GTPase-activating protein 1
1416577_a_at 5908 (± 412) 11936 (± 1884) 0.0056 2.02 Rbx1 ring-box 1
1423444_at 1347 (± 351) 657 (± 105) 0.0311 -2.05 Rock1 Rho-associated coiled-coil containing protein kinase 1
1425465_a_at 611 (± 128) 194 (± 73) 0.0080 -3.15 Senp2 SUMO/sentrin specific peptidase 2
1416594_at 722 (± 105) 300 (± 44) 0.0030 -2.41 Sfrp1 secreted frizzled-related protein 1
1422485_at 2828 (± 354) 1189 (± 425) 0.0068 -2.38 Smad4 MAD homolog 4
1434644_at 780 (± 274) 29 (± 15) 0.0090 -27.22 Tbl1x transducin (beta)-like 1 X-linked
1429427_s_at 221 (± 5) 460 (± 97) 0.0132 2.08 Tcf7l2 transcription factor 7-like 2, T-cell specific, HMG-box
1455592_at 1336 (± 506) 306 (± 101) 0.0258 -4.37 Vangl2 vang-like 2 (van Gogh homolog)
1448818_at 212 (± 68) 82 (± 16) 0.0326 -2.60 Wnt5a wingless-related MMTV integration site 5A
1420892_at 645 (± 120) 213 (± 15) 0.0035 -3.03 Wnt7b wingless-related MMTV integration site 7B
  1. Components of the Wnt pathway were identified according to KEGG and GenMAPP annotation. Affymetrix probe ID numbers are given for representative probe sets. Means of signal intensities and standard deviations were rounded the next full figure; p-values were rounded to the fourth digit after the period except where otherwise indicated; fold-change values were rounded to the second digit after the period. Negative fold-change values indicate reduced expression level in diabetes-exposed embryos.