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Figure 7 | BMC Genomics

Figure 7

From: Impact of animal strain on gene expression in a rat model of acute cardiac rejection

Figure 7

Thematic analysis of differentially expressed genes. (A) Pathway analysis in heart tissue of differentially expressed genes associated with strain effect, or rejection effect or overlap region. (B) Pathway analysis of differentially expressed genes in peripheral blood mononuclear cells (PBMC) associated with strain alone or strain plus rejection or both (overlap region). Genes tested are grouped and color coded as defined by the Venn diagrams shown in Figure 3. For each graph, the threshold for significance is 1.3 representing – log 0.05 (unadjusted p = 0.05). In heart tissue, the over-represented functional categories such as immune response and cell death were more strongly associated with rejection than with the strain effect. Conversely in PBMC, strain effect was strongly linked to pathways indicative of immune response and cell death both in the presence and absence of rejection. Results based on an Ingenuity® Systems Pathway Analysis (see Methods).

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