Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm

Table 2 Examples of genes differentially expressed between paired supra and infrarenal aortas.

Symbol	Gene ID	Gene Name	Mean expression ratio*	P value
Adprhl1	234072	ADP-ribosylhydrolase like 1	3.11	0.015
Lgtn	16865	Ligatin	2.91	0.041
Fabp3	14077	Fatty acid binding protein 3	1.86	0.043
Pik3ap1†	83490	phosphoinositide-3-kinase adaptor protein 1	1.85	0.030
Dapk1†	69635	Death associated protein kinase 1 (Dapk1)	1.73	0.028
Tuba8	53857	tubulin, alpha 8	1.68	0.045
Cd59a†	12509	CD59a antigen	1.68	0.007
Cxcl13	55985	chemokine (C-X-C motif) ligand 13	1.56	0.021
Tgfbr3†	21814	Transforming growth factor, beta receptor III	1.53	0.030
Myo18b	74376	myosin XVIIIb	0.59	0.006
Ucn3	83428	urocortin 3	0.57	0.022
Srd5a2	94224	steroid 5 alpha-reductase 2	0.56	0.029
Dsc3	13507	desmocollin 3	0.52	0.037
Lama3†	16774	laminin, alpha 3	0.52	0.025
Trat1†	77647	T cell receptor associated transmembrane adaptor 1	0.51	0.008
Shbg	20415	sex hormone binding globulin	0.42	0.034
Akr1b7	11997	aldo-keto reductase family 1, member B7	0.24	< 0.001

Shown are a subset of the 304 gene transcripts that were differentially expressed in suprarenal compared to infrarenal aortic segments (1.5-fold, uncorrected p value < 0.05 calculated with paired t-test; for a full list see Additional File 1). The genes were selected from the full list based on the potential relevance to AAA. Genes highlighted with † have previously been identified as associated with human AAA in a whole genome expression study [9]. *Ratio of relative gene expression in supra compared to infrarenal aortic segments from 10 paired samples (5 pairs of arrays due to pooling of 2 aortic segments for each analysis).

ISSN: 1471-2164