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Table 2 Examples of genes differentially expressed between paired supra and infrarenal aortas.

From: Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm

Symbol Gene ID Gene Name Mean expression ratio* P value
Adprhl1 234072 ADP-ribosylhydrolase like 1 3.11 0.015
Lgtn 16865 Ligatin 2.91 0.041
Fabp3 14077 Fatty acid binding protein 3 1.86 0.043
Pik3ap1† 83490 phosphoinositide-3-kinase adaptor protein 1 1.85 0.030
Dapk1† 69635 Death associated protein kinase 1 (Dapk1) 1.73 0.028
Tuba8 53857 tubulin, alpha 8 1.68 0.045
Cd59a† 12509 CD59a antigen 1.68 0.007
Cxcl13 55985 chemokine (C-X-C motif) ligand 13 1.56 0.021
Tgfbr3† 21814 Transforming growth factor, beta receptor III 1.53 0.030
Myo18b 74376 myosin XVIIIb 0.59 0.006
Ucn3 83428 urocortin 3 0.57 0.022
Srd5a2 94224 steroid 5 alpha-reductase 2 0.56 0.029
Dsc3 13507 desmocollin 3 0.52 0.037
Lama3† 16774 laminin, alpha 3 0.52 0.025
Trat1† 77647 T cell receptor associated transmembrane adaptor 1 0.51 0.008
Shbg 20415 sex hormone binding globulin 0.42 0.034
Akr1b7 11997 aldo-keto reductase family 1, member B7 0.24 < 0.001
  1. Shown are a subset of the 304 gene transcripts that were differentially expressed in suprarenal compared to infrarenal aortic segments (1.5-fold, uncorrected p value < 0.05 calculated with paired t-test; for a full list see Additional File 1). The genes were selected from the full list based on the potential relevance to AAA. Genes highlighted with † have previously been identified as associated with human AAA in a whole genome expression study [9]. *Ratio of relative gene expression in supra compared to infrarenal aortic segments from 10 paired samples (5 pairs of arrays due to pooling of 2 aortic segments for each analysis).