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Table 4 Examples of genes upregulated in the aortas of mice with aneurysms.

From: Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm

Gene symbol Gene ID Description; synonym Fold increase cf no AAA P value Fold increase cf saline P value
Chemokines/receptors       
Cxcl10 15945 chemokine (C-X-C motif) ligand 10; IP-10 2.766 0.0284 2.487 0.0374
Cxcl12 20315 chemokine (C-X-C motif) ligand 12; SDF-1 3.022 0.0121 3.03 0.00358
Cxcl14 57266 chemokine (C-X-C motif) ligand 14; MIP-2g 3.812 0.0092 2.801 0.0373
Ccl2 20296 chemokine (C-C motif) ligand 2; MCP-1 2.263 0.021 3.325 0.00493
Ccl4 20303 chemokine (C-C motif) ligand 4; MIP-1B 4.232 0.0154 7.864 0.00302
Ccl7 20306 chemokine (C-C motif) ligand 7; MCP-3 3.183 0.00247 5.009 0.000346
Ccl8 20307 chemokine (C-C motif) ligand 8; MCP-2 3.12 0.00645 3.911 0.000657
Ccl19 24047 chemokine (C-C motif) ligand 19; ELC 2.119 0.00758 2.629 0.00228
Ccl21a 65956 chemokine (C-C motif) ligand 21; SLC 3.577 0.000615 2.66 0.0052
Cx3cr1 13051 Cx3cr1 2.602 0.00131 3.99 0.000356
Ccr5 12774 CD195 2.224 0.00187 3.358 0.000184
MMPs       
Mmp2 17390 matrix metalloproteinase 2 2.513 0.000969 3.123 0.000609
Mmp12 17381 matrix metalloproteinase 12 2.172 0.0232 7.993 0.00031
Mmp13 17386 matrix metalloproteinase 13 6.428 0.02 13.62 0.00657
Mmp14 17387 matrix metalloproteinase 14 2.345 0.00432 3.99 0.000764
Cell lineage       
Cd14 12475 CD14 antigen 2.068 0.00045 2.549 4.29E-05
Cd68 12514 CD68 antigen 2.907 0.00865 5.776 0.00162
Csf3r 12986 colony stimulating factor 3 receptor (granulocyte); CD114. 2.627 9.99E-05 2.53 0.00056
FceR1g 14127 Fc receptor, IgE, high affinity I, gamma polypeptide; CD23 2.835 0.0275 3.691 0.0125
Anpep 16790 alanyl (membrane) aminopeptidase; CD13 2.216 0.000594 3.312 5.46E-05
Cytokines and receptors       
Il6 16193 interleukin 6 2.61 0.0411 3.92 0.0136
Il1b 16176 interleukin 1 beta 3.966 0.0158 5.89 0.00501
Antigen processing and presentation       
Cd74 16149 Ia-associated invariant chain 2.376 0.00037 2.488 7.03E-05
H2-Ab1 14961 histocompatibility 2, class II antigen A, beta 1 2.799 0.000852 3.108 5.10E-06
  1. Shown are genes which were significantly up-regulated (2-fold, uncorrected p value < 0.05 calculated with unpaired t-test) within the aortas of mice with AAAs by comparison to both mice that received angiotensin II and did not develop AAAs and also saline control mice. Genes were selected from the full list of differentially expressed genes (shown in Additional Files 3 and 4) based on their upregulation in both comparisons, likely functional importance and previous association with human AAA. Transcripts associated with no recognised gene are not included. Genes highlighted with † have previously been identified as associated with human AAA in a whole genome expression study or other human AAA studies [9, 10]. Genes highlighted in bold were selected for validation by real time PCR (see Table 6). Cf: compared to; ns: not significant