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Table 4 Examples of genes upregulated in the aortas of mice with aneurysms.

From: Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm

Gene symbol

Gene ID

Description; synonym

Fold increase cf no AAA

P value

Fold increase cf saline

P value

Chemokines/receptors

      

Cxcl10

15945

chemokine (C-X-C motif) ligand 10; IP-10

2.766

0.0284

2.487

0.0374

Cxcl12

20315

chemokine (C-X-C motif) ligand 12; SDF-1

3.022

0.0121

3.03

0.00358

Cxcl14

57266

chemokine (C-X-C motif) ligand 14; MIP-2g

3.812

0.0092

2.801

0.0373

Ccl2†

20296

chemokine (C-C motif) ligand 2; MCP-1

2.263

0.021

3.325

0.00493

Ccl4 †

20303

chemokine (C-C motif) ligand 4; MIP-1B

4.232

0.0154

7.864

0.00302

Ccl7

20306

chemokine (C-C motif) ligand 7; MCP-3

3.183

0.00247

5.009

0.000346

Ccl8 †

20307

chemokine (C-C motif) ligand 8; MCP-2

3.12

0.00645

3.911

0.000657

Ccl19

24047

chemokine (C-C motif) ligand 19; ELC

2.119

0.00758

2.629

0.00228

Ccl21a

65956

chemokine (C-C motif) ligand 21; SLC

3.577

0.000615

2.66

0.0052

Cx3cr1

13051

Cx3cr1

2.602

0.00131

3.99

0.000356

Ccr5†

12774

CD195

2.224

0.00187

3.358

0.000184

MMPs

      

Mmp2 †

17390

matrix metalloproteinase 2

2.513

0.000969

3.123

0.000609

Mmp12

17381

matrix metalloproteinase 12

2.172

0.0232

7.993

0.00031

Mmp13

17386

matrix metalloproteinase 13

6.428

0.02

13.62

0.00657

Mmp14

17387

matrix metalloproteinase 14

2.345

0.00432

3.99

0.000764

Cell lineage

      

Cd14†

12475

CD14 antigen

2.068

0.00045

2.549

4.29E-05

Cd68†

12514

CD68 antigen

2.907

0.00865

5.776

0.00162

Csf3r

12986

colony stimulating factor 3 receptor (granulocyte); CD114.

2.627

9.99E-05

2.53

0.00056

FceR1g†

14127

Fc receptor, IgE, high affinity I, gamma polypeptide; CD23

2.835

0.0275

3.691

0.0125

Anpep

16790

alanyl (membrane) aminopeptidase; CD13

2.216

0.000594

3.312

5.46E-05

Cytokines and receptors

      

Il6†

16193

interleukin 6

2.61

0.0411

3.92

0.0136

Il1b†

16176

interleukin 1 beta

3.966

0.0158

5.89

0.00501

Antigen processing and presentation

      

Cd74

16149

Ia-associated invariant chain

2.376

0.00037

2.488

7.03E-05

H2-Ab1†

14961

histocompatibility 2, class II antigen A, beta 1

2.799

0.000852

3.108

5.10E-06

  1. Shown are genes which were significantly up-regulated (2-fold, uncorrected p value < 0.05 calculated with unpaired t-test) within the aortas of mice with AAAs by comparison to both mice that received angiotensin II and did not develop AAAs and also saline control mice. Genes were selected from the full list of differentially expressed genes (shown in Additional Files 3 and 4) based on their upregulation in both comparisons, likely functional importance and previous association with human AAA. Transcripts associated with no recognised gene are not included. Genes highlighted with † have previously been identified as associated with human AAA in a whole genome expression study or other human AAA studies [9, 10]. Genes highlighted in bold were selected for validation by real time PCR (see Table 6). Cf: compared to; ns: not significant
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BMC Genomics

ISSN: 1471-2164

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