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Table 5 Examples of genes upregulated in the aortas of mice exposed to angiotensin II which did not develop aneurysms. These genes are potentially protective against AAA.

From: Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm

Gene symbol

Gene ID

Description

Fold increase cf AAA

P value

Fold increase cf saline

P value

Cald1†

109624

caldesmon 1

2.053388

0.000625

2.379

5.64E-06

Acta2†

11475

actin, alpha 2, smooth muscle, aorta

2.178649

0.0284

2.536

1.84E-06

Sost†

74499

sclerostin

2.659574

0.0118

2.167

9.01E-06

Kcnmb1†

16533

potassium large conductance calcium-activated channel, subfamily M, beta member 1.

2.004008

0.0129

2.262

7.45E-07

Dstn†

56431

destrin

2.169197

0.00498

2.242

6.70E-06

Timp4†

110595

tissue inhibitor of metalloproteinase 4

2

1.99E-05

ns

ns

Pdlim3†

53318

PDZ and LIM domain 3

2.12766

0.00386

ns

ns

Rgs17†

56533

regulator of G-protein signaling 17

2.439024

0.00106

ns

ns

Hspa1l

15482

heat shock protein 1-like

2.020202

0.00844

ns

ns

Gabra3

14396

gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 3

2.028398

0.00482

ns

ns

Btc†

12223

betacellulin, epidermal growth factor family member

2.314815

0.0412

ns

ns

Fbxo30

71865

F-box protein 30

2.325581

0.000911

ns

ns

Hspa1†a

193740

heat shock protein 1A

2.262443

0.00944

ns

ns

Mtap1b†

17755

microtubule-associated protein 1B

2.252252

0.0363

ns

ns

Xirp1

22437

cardiomyopathy associated 1

2.155172

0.0165

ns

ns

Klk10

69540

Kallikrein 10

2.136752

7.42E-05

ns

ns

Slc22a1†

20517

solute carrier family 22 (organic cation transporter), member 1

2.873563

0.000794

ns

ns

  1. Shown are examples of genes which were significantly up-regulated (2-fold, uncorrected p value < 0.05 calculated with unpaired t-test) within the aortas of mice that received angiotensin II and did not develop AAAs by comparison to mice which developed AAAs. Also shown is comparison with findings from the aortas of saline control mice. Genes were selected from the full list of differentially expressed genes (shown in Additional File 9) based on their likely functional importance and previous association with human AAA. Genes highlighted with † have previously been identified as down-regulated within human AAA in a whole genome expression study [9]. Cf: compared to; ns: not significant.