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Table 5 Examples of genes upregulated in the aortas of mice exposed to angiotensin II which did not develop aneurysms. These genes are potentially protective against AAA.

From: Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm

Gene symbol Gene ID Description Fold increase cf AAA P value Fold increase cf saline P value
Cald1 109624 caldesmon 1 2.053388 0.000625 2.379 5.64E-06
Acta2 11475 actin, alpha 2, smooth muscle, aorta 2.178649 0.0284 2.536 1.84E-06
Sost 74499 sclerostin 2.659574 0.0118 2.167 9.01E-06
Kcnmb1 16533 potassium large conductance calcium-activated channel, subfamily M, beta member 1. 2.004008 0.0129 2.262 7.45E-07
Dstn 56431 destrin 2.169197 0.00498 2.242 6.70E-06
Timp4 110595 tissue inhibitor of metalloproteinase 4 2 1.99E-05 ns ns
Pdlim3 53318 PDZ and LIM domain 3 2.12766 0.00386 ns ns
Rgs17 56533 regulator of G-protein signaling 17 2.439024 0.00106 ns ns
Hspa1l 15482 heat shock protein 1-like 2.020202 0.00844 ns ns
Gabra3 14396 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 3 2.028398 0.00482 ns ns
Btc 12223 betacellulin, epidermal growth factor family member 2.314815 0.0412 ns ns
Fbxo30 71865 F-box protein 30 2.325581 0.000911 ns ns
Hspa1a 193740 heat shock protein 1A 2.262443 0.00944 ns ns
Mtap1b 17755 microtubule-associated protein 1B 2.252252 0.0363 ns ns
Xirp1 22437 cardiomyopathy associated 1 2.155172 0.0165 ns ns
Klk10 69540 Kallikrein 10 2.136752 7.42E-05 ns ns
Slc22a1 20517 solute carrier family 22 (organic cation transporter), member 1 2.873563 0.000794 ns ns
  1. Shown are examples of genes which were significantly up-regulated (2-fold, uncorrected p value < 0.05 calculated with unpaired t-test) within the aortas of mice that received angiotensin II and did not develop AAAs by comparison to mice which developed AAAs. Also shown is comparison with findings from the aortas of saline control mice. Genes were selected from the full list of differentially expressed genes (shown in Additional File 9) based on their likely functional importance and previous association with human AAA. Genes highlighted with † have previously been identified as down-regulated within human AAA in a whole genome expression study [9]. Cf: compared to; ns: not significant.