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Table 6 Validation of genes up-regulated in AAA by real time PCR.

From: Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm

Gene symbol Gene ID Description; synonym Relative expression in AAA Relative expression in no AAA Relative expression in saline control P value AAA v no AAA P value AAA v saline control
Ccl4 20303 chemokine (C-C motif) ligand 4; MIP-1B 52.71 (19.80–133.40) 5.55 (4.87–9.91) 1.40 (0.84–2.49) 0.009 0.004
Ccl8 20307 chemokine (C-C motif) ligand 8; MCP-2 8.84 (5.94–12.25) 1.66 (1.27–2.73) 0.84 (0.55–1.18) 0.009 0.004
Mmp2 17390 matrix metalloproteinase 2 4.58 (3.80–11.00) 2.30 (1.50–3.17) 0.97 (0.81–1.06) 0.004 0.004
Il6 16193 interleukin 6 70.87 (14.40–184.59) 9.49 (2.54–16.83) 0.46 (0.17–1.26) 0.030 0.004
  1. Shown are median (inter-quartile range) of relative gene expression (compared to house-keeping gene) in whole aortas used in the micro-array studies removed from mice exposed to angiotensin II that developed AAAs (n = 5) or no AAA (n = 7) or saline controls (n = 6).