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Table 7 Top 10 KEGG pathways enriched in mouse aortic aneurysms.

From: Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm

Pathway (KEGG linked) Total genes in pathway Number genes upregulated in pathway in AAA v no AAA Representative Genes (Entrez Gene ID) P value*
Cytokine-cytokine receptor interaction 249 28 Cxcl5 (20311), Cxcl9 (17329), Cxcl10 (15945), Cxcl12 (20315), Cxcl13 (55985), Cxcl16 (66102), Cxcl14 (57266), Xcl1(16963), Cx3cr1 (13051), Cxcr4 (12767), Ccl19(24047), Ccl21a (20298), Ccl21b (18829), Ccl2 (20296), Ccl12 (20293), Ccl4 (20303), Ccl7 (20306), Ccl5 (20304), Ccl8 (20307), Ccr5 (12774), Il6 (16193), Csf3r (12986), Csf2rb2 (12984), Il7r (16197), Il2rg (16186), Il10ra (16154), Tnfrsf13b (57916), Il1b (16176) 8.70e-26
Leukocyte transendothelial migration 115 15 Cldn11 (18417), Mmp2 (17390), Mmp9 (17395), Ptpn11, Cybb (13058), Ncf2 (17970), Ncf4 (17972), Thy1 (21838), Cxcl12 (20315), Cxcr4 (12767), Rac2 (19354), Vav1 (22324), Ptk2b(19229), Cxcl13 (55985), Cxcl14 (57266) 4.20e-15
Focal adhesion 194 11 Col3a1 (12825), Col1a1 (12842), Comp (12845), Reln (19699), Thbs1 (21825), Thbs2 (21826), Igf1 (16000), Igf1r (16000), Vav1 (22324), Rac2 (19354), Itga11(319480), Itga6 (16403) 1.22e-7
B cell receptor signaling pathway 69 10 Cd72(12517), Cd79b (15985), Fcgr2b (14130), Inpp5d(16331), Btk (12229), Blnk (17060), Vav1(22324), Rac2(19354), Rasgrp3(240168), Ifitm1(68713) 3.75e-11
Natural killer cell mediated cytotoxicity 129 10 Hcst (23900), Klrd1 (16643), Fcgr3(14131), Fcer1g (14127), Tyrobp (22177, Ptk2b (19229), Vav1 (22324), Lcp2(16822), Cd48 (12506), Rac2 (19354) 8.70e-9
Hematopoietic cell lineage 86 10 H2-Eb1(14969), Il7r (16197), Cd3d (12500), Fcgr1(14129), Anpep (16790), Il6 (16193), Il1b(16176), Csf3r (12986), Itga6(16403), Cd14(12475) 3.24e-10
Jak-STAT signaling pathway 155 8 Il6(16193), Csfrb2(12984), Csf3r(12986), Il10ra(16154), Il2rg(16186), Il7r(16197), Jak3 (16453), Socs3(12702) 1.18e-6
ECM-receptor interaction 81 8 Reln(19699), Itga11(319480), Itga6(16403), Col3a1(12825), Col1a1(12842), Thbs1(21825), Thbs2(21826), Sdc3(20970) 1.43e-7
Toll-like receptor signaling pathway 101 7 Cd14(12475), Il6 (16193), Il1b(16176), Ccl5(20304), Ccl4(20303), Cxcl10(15945), Cxcl9(17329), 3.52e-6
Cell adhesion molecules (CAMs) 158 7 H2-Ab1(14961), H2-Eb1(14969), H2-DMb1(14999), Selpl (20345), Sdc3(20970), Itga6(16403), Cldn11(18417) 4.42e-5
  1. Pathways were identified using WebGestalt by comparison of differentially expressed genes in the aortas of mice that did and did not develop aneurysms following angiotensin II infusion. Transcripts with >2 fold increase in expression in AAA compared to no AAA and p < 0.05 were submitted for pathway analysis. Pathways are linked to the KEGG website http://www.genome.jp and genes are linked to gene information. P value indicates the uncorrected significance of enrichment calculated from the hypergeometric test.