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Table 7 Top 10 KEGG pathways enriched in mouse aortic aneurysms.

From: Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm

Pathway (KEGG linked)

Total genes in pathway

Number genes upregulated in pathway in AAA v no AAA

Representative Genes (Entrez Gene ID)

P value*

Cytokine-cytokine receptor interaction

249

28

Cxcl5 (20311), Cxcl9 (17329), Cxcl10 (15945), Cxcl12 (20315), Cxcl13 (55985), Cxcl16 (66102), Cxcl14 (57266), Xcl1(16963), Cx3cr1 (13051), Cxcr4 (12767), Ccl19(24047), Ccl21a (20298), Ccl21b (18829), Ccl2 (20296), Ccl12 (20293), Ccl4 (20303), Ccl7 (20306), Ccl5 (20304), Ccl8 (20307), Ccr5 (12774), Il6 (16193), Csf3r (12986), Csf2rb2 (12984), Il7r (16197), Il2rg (16186), Il10ra (16154), Tnfrsf13b (57916), Il1b (16176)

8.70e-26

Leukocyte transendothelial migration

115

15

Cldn11 (18417), Mmp2 (17390), Mmp9 (17395), Ptpn11, Cybb (13058), Ncf2 (17970), Ncf4 (17972), Thy1 (21838), Cxcl12 (20315), Cxcr4 (12767), Rac2 (19354), Vav1 (22324), Ptk2b(19229), Cxcl13 (55985), Cxcl14 (57266)

4.20e-15

Focal adhesion

194

11

Col3a1 (12825), Col1a1 (12842), Comp (12845), Reln (19699), Thbs1 (21825), Thbs2 (21826), Igf1 (16000), Igf1r (16000), Vav1 (22324), Rac2 (19354), Itga11(319480), Itga6 (16403)

1.22e-7

B cell receptor signaling pathway

69

10

Cd72(12517), Cd79b (15985), Fcgr2b (14130), Inpp5d(16331), Btk (12229), Blnk (17060), Vav1(22324), Rac2(19354), Rasgrp3(240168), Ifitm1(68713)

3.75e-11

Natural killer cell mediated cytotoxicity

129

10

Hcst (23900), Klrd1 (16643), Fcgr3(14131), Fcer1g (14127), Tyrobp (22177, Ptk2b (19229), Vav1 (22324), Lcp2(16822), Cd48 (12506), Rac2 (19354)

8.70e-9

Hematopoietic cell lineage

86

10

H2-Eb1(14969), Il7r (16197), Cd3d (12500), Fcgr1(14129), Anpep (16790), Il6 (16193), Il1b(16176), Csf3r (12986), Itga6(16403), Cd14(12475)

3.24e-10

Jak-STAT signaling pathway

155

8

Il6(16193), Csfrb2(12984), Csf3r(12986), Il10ra(16154), Il2rg(16186), Il7r(16197), Jak3 (16453), Socs3(12702)

1.18e-6

ECM-receptor interaction

81

8

Reln(19699), Itga11(319480), Itga6(16403), Col3a1(12825), Col1a1(12842), Thbs1(21825), Thbs2(21826), Sdc3(20970)

1.43e-7

Toll-like receptor signaling pathway

101

7

Cd14(12475), Il6 (16193), Il1b(16176), Ccl5(20304), Ccl4(20303), Cxcl10(15945), Cxcl9(17329),

3.52e-6

Cell adhesion molecules (CAMs)

158

7

H2-Ab1(14961), H2-Eb1(14969), H2-DMb1(14999), Selpl (20345), Sdc3(20970), Itga6(16403), Cldn11(18417)

4.42e-5

  1. Pathways were identified using WebGestalt by comparison of differentially expressed genes in the aortas of mice that did and did not develop aneurysms following angiotensin II infusion. Transcripts with >2 fold increase in expression in AAA compared to no AAA and p < 0.05 were submitted for pathway analysis. Pathways are linked to the KEGG website http://www.genome.jp and genes are linked to gene information. P value indicates the uncorrected significance of enrichment calculated from the hypergeometric test.
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BMC Genomics

ISSN: 1471-2164

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