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Table 8 Comparison of results from this study and those from other expression arrays for AAA.

From: Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm

Ref.

Transcripts examined

Species

Number of samples/controls

Tissue of interest

Control tissue

Similar genes upregulated

9

18057 oligonucleotides microarray

Human

6/7

AAA

Normal#

Chemokines (e.g. CCL2, CCL4, CCL8, CCR5, CXCL5, CXCR4, TNFRSF13B)

Pro-inflammatory cytokines (e.g. IL1B, IL2RG)

Matrix metalloproteinase (e.g. MMP9)

Cell lineage markers (e.g. CD53, CD68, CD72)

32‡

1181 cDNA clones

Mice

3/3**

Elastase induced AAA

Inactivated elastase infused aortas

Pro-inflammatory cytokines (e.g. IL1B, IL6, INF, IGF1)

Chemokines (e.g. CCL7)

JAK-STAT signalling (e.g. SOC3)

31‡

375 cDNA clones

Human

1/1*

AAA body

AAA neck

Chemokines (e.g. CXCR2)

28‡

265 cDNA clones

Human

7/5/5†

AAA

AOD and normal†

Matrix metalloproteinase (e.g. MMP9, MMP12)

Pro-inflammatory cytokines (e.g. IL1B, IL6)

Chemokines (e.g. CCL4, CCR5)

Fibrinolysis (e.g. uPA)

33‡

8799 cDNA clones microarray

Rat

1/1‡‡

Elastase induced AAA

Saline infused aortas

Oxidative stress (Heme oxygenase, lipoxygenase)

34‡

1176 cDNA clones

Human

4/4

AAA

normal††

Cathepsins (e.g. cathepsin H)

Matrix metalloproteinase (e.g. MMP9)

Chemokines (e.g. CXCR4, CCL5)

  1. *Results provided limited; †5 controls from aortic occlusive disease (AOD) from patients undergoing bypass and 5 controls from organ donors which were not age-matched; ‡These studies did not adjust for multiple testing; **pooling of samples was performed with 3 pools of interest compared with 3 controls for 4 different time periods after elastase infusion; ††Controls were from organ donor who were not matched; ‡‡Appears to have been comparison of one pool of samples from elastase induced aaas and one pool from controls examined on two microarrays each; #controls from post-mortem samples. Ref. = reference.