Figure 2

Comparison of predicted proteomes by BLAST-score ratio (BSR) analysis. The left panel shows a BSR analysis of proteins encoded by strain J99 and HPAG1, with strain 26695 as the reference strain. The right panel shows a BSR analysis of proteins encoded by strain 98-10 and B128, with strain 26695 as the reference strain. The BSR approach analyzes all proteins predicted to be encoded by three genomes, using a measure of similarity based on the ratio of BLAST scores, as described in the Methods. Proteins depicted within the box at the lower left corner (BSR <0.4) correspond to proteins present in the reference proteome (strain 26695) but absent from the two query proteomes. The upper right quadrant represents proteins conserved in all three proteomes.