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Table 1 Features of H. pylori genomes

From: Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer

 

H. pylori strain

 

26695

J99

HPAG1

98-10

B128

Origin

U.K.

U.S.

Sweden

Japan

U.S.

Disease statea

Gastritis only

DU

AG

GC

GU

cag PAI

Yes

Yes

Yes

Yes

Yes

vacA genotype

s1a/m1

s1b/m1

s1b/m1

s1c/m1

s1a/m2h

Genome size (Mb)

1.67

1.64

1.61b

1.6c

1.6c

Total no. of ORFs

1564d

1491e

1544f

1527

1731

No. of strain-specific genesg

69

23

38

22

51

  1. a DU, duodenal ulcer; AG, atrophic gastritis; GC, gastric cancer; GU, gastric ulcer
  2. b Includes a 9.3 kb plasmid.
  3. c The genome size of strain 98-10 is based on analysis of 51 large contigs, as defined in Methods. The genome size of strain B128 is based on analysis of 73 large contigs.
  4. d The current analysis is based on data downloaded from TIGR, comprising 1564 ORFs. In contrast, a table on the TIGR website lists 1587 ORFs in strain 26695, and Genbank sequence files include 1566 ORFs from strain 26695.
  5. e Additional ORFs, not included in this total, were subsequently detected in strain J99 [43].
  6. f The HPAG1 chromosome contains 1,536 predicted protein-coding genes, and the remainder are contained on a plasmid.
  7. g Present in only one of five strains analyzed in this study.
  8. h vacA is truncated in strain B128.