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Table 2 Number of genes over-expressed in xenografts excised from GLV-1h68 infected animals

From: Systemic treatment of xenografts with vaccinia virus GLV-1h68 reveals the immunologic facet of oncolytic therapy

Experimental group Days after VACV inj.     
VACGLa 520445F, Affymetrix platform VACV only Permutation House keeping (human/mouse) Permutation
(cut off p2-value < 0.005 (unpaired Student t test)   (∑ 219) test p-value (∑ 337) test p-value
GI-101A 7 0 N.S. 3 N.S.
GI-101A 21 219 < 0.001 (232) < 0.001
GI-101A 42 216 < 0.001 (237) < 0.001
HT-29 21 0 N.S. (3) N.S.
HT-29 42 0 N.S. (10) N.S.
37 K whole genome HUMAN array   All genes Permutation   
(cut off p2-value < 0.001 (unpaired Student t test)   (∑ 37 K) test p-value   
GI-101A 21 136 < 0.05   
GI-101A 42 91 < 0.05   
HT-29 21 4 N.S.   
HT-29 42 10 N.S.   
37 K whole genome Mouse array   All genes Permutation   
(cut off p2-value < 0.001 (unpaired Student t test)   (∑ 37 K) test p-value   
GI-101A 21 105 < 0.05   
GI-101A 42 1026 < 0.001   
HT-29 21 7 N.S.   
HT-29 42 14 N.S.   
  1. * In parenthesis, genes down-regulated in GLV-1h68-infected animals referring to human/mouse house-keeping genes in the VACV chip