Table 3 Mouse immune genes up-regulated in regressing GI-101A tumors at day 21 (F test p2-value < 0.001)
Gene LLID # | Symbol | Name | HT-29 Control | HT-29 GLV-1h68 | GI-101A Control | GI-101A GLV-1h68 |
|---|---|---|---|---|---|---|
Interleukins | Â | Â | Â | Â | Â | Â |
16068 | Il18bp | interleukin 18 binding protein | 0.58 | 0.98 | 1.00 | 5.70 |
16173 | Il18 | Il18 – interleukin 18 | 1.24 | 1.25 | 1.00 | 4.10 |
Chemokines | Â | Â | Â | Â | Â | Â |
20296 | Ccl2 | Ccl2/MCP-1 (human nomenclature) | 1.65 | 2.12 | 1.00 | 10.84 |
20292 | Ccl11 | Ccl11/Eotaxin | 0.64 | 1.10 | 1.00 | 9.47 |
20307 | Ccl8 | Ccl8/MCP-2 | 1.51 | 3.30 | 1.00 | 7.16 |
| Â | Cxcl11 | CXCL11/-ITAC | 0.82 | 1.04 | 1.00 | 5.69 |
17329 | Ccl12 | Ccl12/MCP-5 | 1.22 | 1.44 | 1.00 | 4.97 |
20306 | Ccl7 | Ccl7/MCP-3.MARC | 0.72 | 0.90 | 1.00 | 4.71 |
| Â | Cxcl10 | Cxcl10/IP-10 | 0.83 | 0.84 | 1.00 | 4.08 |
17329 | Cxcl9 | Cxcl9/Mig | 0.72 | 0.72 | 1.00 | 3.80 |
20308 | Ccl9 | Ccl9/MRP-2/CCF18/MIP-1g | 1.06 | 1.08 | 1.00 | 3.12 |
20315 | Cxcl12 | Cxcl12/SDF-1/PBSF | 0.75 | 0.84 | 1.00 | 3.07 |
20304 | Ccl5 | Ccl5/RANTES | 0.66 | 0.97 | 1.00 | 2.56 |
ISGs | Â | Â | Â | Â | Â | Â |
16145 | Igtp | interferon gamma induced GTPase | 0.50 | 1.13 | 1.00 | 10.11 |
76933 | Ifi27 | interferon, alpha-inducible protein 27 | 0.87 | 1.14 | 1.00 | 10.04 |
231655 | Oasl1 | 2'-5' oligoadenylate synthetase-like 1 | 0.66 | 0.73 | 1.00 | 6.93 |
17857 | Mx1 | myxovirus (influenza virus) resistance 1 | 0.77 | 0.89 | 1.00 | 6.41 |
16145 | Igtp | interferon gamma induced GTPase | 0.89 | 0.80 | 1.00 | 5.62 |
| Â | Ifi204 | interferon activated gene 204 | 0.71 | 1.06 | 1.00 | 5.44 |
246730 | Oas1a | 2'-5' oligoadenylate synthetase 1A | 0.64 | 1.16 | 1.00 | 5.38 |
| Â | Iigp2 | interferon inducible GTPase 2 | 0.63 | 0.83 | 1.00 | 5.25 |
26388 | Ifi202b | interferon activated gene 202B | 0.54 | 1.17 | 1.00 | 4.61 |
| Â | Ifi47 | interferon gamma inducible protein 47 | 0.54 | 0.67 | 1.00 | 4.56 |
15957 | Ifit1 | interferon-induced protein with tetratricopeptide repeats 1 | 1.06 | 0.94 | 1.00 | 4.15 |
20847 | Stat2 | signal transducer and activator of transcription 2 | 0.81 | 0.85 | 1.00 | 4.06 |
20846 | Stat1 | signal transducer and activator of transcription 1 | 0.74 | 0.68 | 1.00 | 4.02 |
16362 | Irf1 | interferon regulatory factor 1 | 0.91 | 1.21 | 1.00 | 3.78 |
65972 | Ifi30 | interferon gamma inducible protein 30 | 0.64 | 0.70 | 1.00 | 3.67 |
246728 | Oas2 | 2'-5' oligoadenylate synthetase 2 | 1.08 | 1.10 | 1.00 | 3.29 |
Other | Â | Â | Â | Â | Â | Â |
17067 | Ly6c | lymphocyte antigen 6 complex, locus C | 0.90 | 0.99 | 1.00 | 5.77 |
17067 | Ly6c | Lymphocyte antigen 6 complex, locus C | 0.95 | 1.12 | 1.00 | 5.27 |
17071 | Ly6f | lymphocyte antigen 6 complex, locus F | 1.01 | 1.08 | 1.00 | 5.01 |
20715 | Serpina3g | serine (or cysteine) peptidase inhibitor, clade A, member 3G | 0.88 | 0.68 | 1.00 | 4.77 |
18636 | Cfp | complement factor properdin | 0.75 | 0.86 | 1.00 | 4.62 |
15331 | Hmgn2 | high mobility group nucleosomal binding domain 2 | 1.05 | 1.05 | 1.00 | 4.30 |
13032 | Ctsc | cathepsin C | 0.60 | 0.60 | 1.00 | 4.24 |
64685 | Nmi | N-myc (and STAT) interactor | 1.04 | 1.11 | 1.00 | 4.12 |
20343 | Sell | selectin, lymphocyte | 0.95 | 0.75 | 1.00 | 3.91 |
12370 | Casp8 | caspase 8 | 0.82 | 0.51 | 1.00 | 3.74 |
16423 | Cd47 | CD47 antigen (Rh-related antigen, integrin-associated signal transducer) | 0.89 | 0.83 | 1.00 | 3.72 |
14962 | Cfb | complement factor B | 0.77 | 0.89 | 1.00 | 3.58 |
| Â | Pla2g7 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | 0.66 | 0.53 | 1.00 | 3.55 |
13025 | Ctla2b | Cytotoxic T lymphocyte-associated protein 2 beta | 0.64 | 1.03 | 1.00 | 3.40 |
18595 | Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.98 | 1.99 | 1.00 | 3.34 |
12267 | C3ar1 | complement component 3a receptor 1 | 0.72 | 0.84 | 1.00 | 3.34 |
16653 | Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 2.15 | 1.36 | 1.00 | 3.22 |
64138 | Ctsz | cathepsin Z | 0.50 | 0.43 | 1.00 | 3.11 |