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Table 3 Mouse immune genes up-regulated in regressing GI-101A tumors at day 21 (F test p2-value < 0.001)

From: Systemic treatment of xenografts with vaccinia virus GLV-1h68 reveals the immunologic facet of oncolytic therapy

Gene LLID # Symbol Name HT-29 Control HT-29 GLV-1h68 GI-101A Control GI-101A GLV-1h68
Interleukins       
16068 Il18bp interleukin 18 binding protein 0.58 0.98 1.00 5.70
16173 Il18 Il18 – interleukin 18 1.24 1.25 1.00 4.10
Chemokines       
20296 Ccl2 Ccl2/MCP-1 (human nomenclature) 1.65 2.12 1.00 10.84
20292 Ccl11 Ccl11/Eotaxin 0.64 1.10 1.00 9.47
20307 Ccl8 Ccl8/MCP-2 1.51 3.30 1.00 7.16
  Cxcl11 CXCL11/-ITAC 0.82 1.04 1.00 5.69
17329 Ccl12 Ccl12/MCP-5 1.22 1.44 1.00 4.97
20306 Ccl7 Ccl7/MCP-3.MARC 0.72 0.90 1.00 4.71
  Cxcl10 Cxcl10/IP-10 0.83 0.84 1.00 4.08
17329 Cxcl9 Cxcl9/Mig 0.72 0.72 1.00 3.80
20308 Ccl9 Ccl9/MRP-2/CCF18/MIP-1g 1.06 1.08 1.00 3.12
20315 Cxcl12 Cxcl12/SDF-1/PBSF 0.75 0.84 1.00 3.07
20304 Ccl5 Ccl5/RANTES 0.66 0.97 1.00 2.56
ISGs       
16145 Igtp interferon gamma induced GTPase 0.50 1.13 1.00 10.11
76933 Ifi27 interferon, alpha-inducible protein 27 0.87 1.14 1.00 10.04
231655 Oasl1 2'-5' oligoadenylate synthetase-like 1 0.66 0.73 1.00 6.93
17857 Mx1 myxovirus (influenza virus) resistance 1 0.77 0.89 1.00 6.41
16145 Igtp interferon gamma induced GTPase 0.89 0.80 1.00 5.62
  Ifi204 interferon activated gene 204 0.71 1.06 1.00 5.44
246730 Oas1a 2'-5' oligoadenylate synthetase 1A 0.64 1.16 1.00 5.38
  Iigp2 interferon inducible GTPase 2 0.63 0.83 1.00 5.25
26388 Ifi202b interferon activated gene 202B 0.54 1.17 1.00 4.61
  Ifi47 interferon gamma inducible protein 47 0.54 0.67 1.00 4.56
15957 Ifit1 interferon-induced protein with tetratricopeptide repeats 1 1.06 0.94 1.00 4.15
20847 Stat2 signal transducer and activator of transcription 2 0.81 0.85 1.00 4.06
20846 Stat1 signal transducer and activator of transcription 1 0.74 0.68 1.00 4.02
16362 Irf1 interferon regulatory factor 1 0.91 1.21 1.00 3.78
65972 Ifi30 interferon gamma inducible protein 30 0.64 0.70 1.00 3.67
246728 Oas2 2'-5' oligoadenylate synthetase 2 1.08 1.10 1.00 3.29
Other       
17067 Ly6c lymphocyte antigen 6 complex, locus C 0.90 0.99 1.00 5.77
17067 Ly6c Lymphocyte antigen 6 complex, locus C 0.95 1.12 1.00 5.27
17071 Ly6f lymphocyte antigen 6 complex, locus F 1.01 1.08 1.00 5.01
20715 Serpina3g serine (or cysteine) peptidase inhibitor, clade A, member 3G 0.88 0.68 1.00 4.77
18636 Cfp complement factor properdin 0.75 0.86 1.00 4.62
15331 Hmgn2 high mobility group nucleosomal binding domain 2 1.05 1.05 1.00 4.30
13032 Ctsc cathepsin C 0.60 0.60 1.00 4.24
64685 Nmi N-myc (and STAT) interactor 1.04 1.11 1.00 4.12
20343 Sell selectin, lymphocyte 0.95 0.75 1.00 3.91
12370 Casp8 caspase 8 0.82 0.51 1.00 3.74
16423 Cd47 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) 0.89 0.83 1.00 3.72
14962 Cfb complement factor B 0.77 0.89 1.00 3.58
  Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.66 0.53 1.00 3.55
13025 Ctla2b Cytotoxic T lymphocyte-associated protein 2 beta 0.64 1.03 1.00 3.40
18595 Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.98 1.99 1.00 3.34
12267 C3ar1 complement component 3a receptor 1 0.72 0.84 1.00 3.34
16653 Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 2.15 1.36 1.00 3.22
64138 Ctsz cathepsin Z 0.50 0.43 1.00 3.11
  1. * In italic transcripts common to day 21 and 42; in bold those unique to each category