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Table 4 Mouse immune genes up-regulated in regressing GI-101A tumors at day 42 (F test p2-value < 0.001)

From: Systemic treatment of xenografts with vaccinia virus GLV-1h68 reveals the immunologic facet of oncolytic therapy

Gene LLID # Symbol Name HT-29 Control HT-29 GLV-1h68 GI-101A Control GI-101A GLV-1h68 GI-101A GLV-1h68 (day 21)
Interleukins        
16068 Il18bp interleukin 18 binding protein 1.31 2.18 1.00 13.28 5.70
16173 Il18 interleukin 18 1.12 1.40 1.00 10.89 4.10
16168 Il15 interleukin 15 1.02 1.51 1.00 5.20 2.86
16154 Il10ra interleukin 10 receptor alpha 0.74 0.90 1.00 3.51 2.08
Chemokines        
  Cxcl11 Cxcl11/I-TAC 0.92 1.75 1.00 13.57 5.69
17329 Cxcl9 Cxcl9/Mig 1.01 1.07 1.00 11.74 3.80
20304 Ccl5 Ccl5/RANTES 1.00 2.69 1.00 13.33 3.23
20308 Ccl9 Ccl9/MRP-2/CCF18/MIP-1g 1.56 3.14 1.00 12.03 6.60
20304 Ccl5 Ccl5/RANTES 1.11 2.57 1.00 9.81 2.56
20306 Ccl7 Ccl7/MARC 0.84 1.18 1.00 5.86 4.71
20315 Cxcl12 Cxcl12/SDF-1/PBSF 0.41 0.58 1.00 5.23 3.07
20301 Ccl27 Ccl27/ALP/CTACK/ILC/Eskine 1.86 1.91 1.00 5.17 1.66
20308 Ccl9 Ccl9/MRP-2/CCF18/MIP-1g 1.26 1.42 1.00 4.04 3.12
ISGs        
16145 Igtp interferon gamma induced GTPase 1.15 3.31 1.00 48.21 10.11
76933 Ifi27 interferon, alpha-inducible protein 27 0.76 0.91 1.00 12.84 10.04
  Ifi47 interferon gamma inducible protein 47 0.66 0.94 1.00 11.09 4.56
  Iigp2 interferon inducible GTPase 2 0.64 1.41 1.00 10.05 5.25
16145 Igtp interferon gamma induced GTPase 0.70 1.28 1.00 9.70 5.62
17857 Mx1 myxovirus (influenza virus) resistance 1 0.62 1.46 1.00 9.46 6.41
  Ifi204 interferon activated gene 204 0.86 1.77 1.00 8.94 5.44
16362 Irf1 interferon regulatory factor 1 0.59 0.98 1.00 7.28 3.78
20846 Stat1 signal transducer and activator of transcription 1 0.57 0.81 1.00 6.84 4.02
20846 Stat1 signal transducer and activator of transcription 1 0.66 0.97 1.00 6.17 2.79
15957 Ifit1 interferon-induced protein with tetratricopeptide repeats 1 0.79 1.03 1.00 5.77 4.15
60440 Iigp1 interferon inducible GTPase 1 0.77 1.00 1.00 4.19 3.00
15976 Ifnar2 Interferon (alpha and beta) receptor 2 1.10 1.60 1.00 3.73 2.19
  Irf5 interferon regulatory factor 5 0.53 0.70 1.00 3.47 2.02
Others        
17071 Ly6f Lymphocyte antigen 6 complex, locus F 0.56 0.73 1.00 8.56 2.68
11629 Aif1 allograft inflammatory factor 1 0.90 1.33 1.00 8.46 2.62
17067 Ly6c Lymphocyte antigen 6 complex, locus C 1.24 1.22 1.00 7.35 5.27
17067 Ly6c lymphocyte antigen 6 complex, locus C 0.99 1.12 1.00 6.03 5.77
17071 Ly6f lymphocyte antigen 6 complex, locus F 0.80 0.89 1.00 5.66 5.01
20343 Sell selectin, lymphocyte 0.61 0.79 1.00 5.03 3.91
76281 Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 1.01 1.51 1.00 5.02 1.98
230233 Ikbkap inhibitor of kappa light polypeptide enhancer in B-cells 0.81 0.93 1.00 4.55 1.43
110454 Ly6a lymphocyte antigen 6 complex, locus A 0.96 0.98 1.00 4.13 2.42
13025 Ctla2b Cytotoxic T lymphocyte-associated protein 2 beta 0.68 1.20 1.00 4.12 3.40
71966 Nkiras2 NFKB inhibitor interacting Ras-like protein 2 1.07 1.27 1.00 3.80 1.93
17087 Ly96 lymphocyte antigen 96 1.13 1.43 1.00 3.77 1.44
17069 Ly6e Lymphocyte antigen 6 complex, locus E 0.77 1.15 1.00 3.28 1.87
  1. * In italic transcripts common to day 21 and 42; in bold those unique to each category