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Table 4 Mouse immune genes up-regulated in regressing GI-101A tumors at day 42 (F test p2-value < 0.001)

From: Systemic treatment of xenografts with vaccinia virus GLV-1h68 reveals the immunologic facet of oncolytic therapy

Gene LLID #

Symbol

Name

HT-29 Control

HT-29 GLV-1h68

GI-101A Control

GI-101A GLV-1h68

GI-101A GLV-1h68 (day 21)

Interleukins

       

16068

Il18bp

interleukin 18 binding protein

1.31

2.18

1.00

13.28

5.70

16173

Il18

interleukin 18

1.12

1.40

1.00

10.89

4.10

16168

Il15

interleukin 15

1.02

1.51

1.00

5.20

2.86

16154

Il10ra

interleukin 10 receptor alpha

0.74

0.90

1.00

3.51

2.08

Chemokines

       
 

Cxcl11

Cxcl11/I-TAC

0.92

1.75

1.00

13.57

5.69

17329

Cxcl9

Cxcl9/Mig

1.01

1.07

1.00

11.74

3.80

20304

Ccl5

Ccl5/RANTES

1.00

2.69

1.00

13.33

3.23

20308

Ccl9

Ccl9/MRP-2/CCF18/MIP-1g

1.56

3.14

1.00

12.03

6.60

20304

Ccl5

Ccl5/RANTES

1.11

2.57

1.00

9.81

2.56

20306

Ccl7

Ccl7/MARC

0.84

1.18

1.00

5.86

4.71

20315

Cxcl12

Cxcl12/SDF-1/PBSF

0.41

0.58

1.00

5.23

3.07

20301

Ccl27

Ccl27/ALP/CTACK/ILC/Eskine

1.86

1.91

1.00

5.17

1.66

20308

Ccl9

Ccl9/MRP-2/CCF18/MIP-1g

1.26

1.42

1.00

4.04

3.12

ISGs

       

16145

Igtp

interferon gamma induced GTPase

1.15

3.31

1.00

48.21

10.11

76933

Ifi27

interferon, alpha-inducible protein 27

0.76

0.91

1.00

12.84

10.04

 

Ifi47

interferon gamma inducible protein 47

0.66

0.94

1.00

11.09

4.56

 

Iigp2

interferon inducible GTPase 2

0.64

1.41

1.00

10.05

5.25

16145

Igtp

interferon gamma induced GTPase

0.70

1.28

1.00

9.70

5.62

17857

Mx1

myxovirus (influenza virus) resistance 1

0.62

1.46

1.00

9.46

6.41

 

Ifi204

interferon activated gene 204

0.86

1.77

1.00

8.94

5.44

16362

Irf1

interferon regulatory factor 1

0.59

0.98

1.00

7.28

3.78

20846

Stat1

signal transducer and activator of transcription 1

0.57

0.81

1.00

6.84

4.02

20846

Stat1

signal transducer and activator of transcription 1

0.66

0.97

1.00

6.17

2.79

15957

Ifit1

interferon-induced protein with tetratricopeptide repeats 1

0.79

1.03

1.00

5.77

4.15

60440

Iigp1

interferon inducible GTPase 1

0.77

1.00

1.00

4.19

3.00

15976

Ifnar2

Interferon (alpha and beta) receptor 2

1.10

1.60

1.00

3.73

2.19

 

Irf5

interferon regulatory factor 5

0.53

0.70

1.00

3.47

2.02

Others

       

17071

Ly6f

Lymphocyte antigen 6 complex, locus F

0.56

0.73

1.00

8.56

2.68

11629

Aif1

allograft inflammatory factor 1

0.90

1.33

1.00

8.46

2.62

17067

Ly6c

Lymphocyte antigen 6 complex, locus C

1.24

1.22

1.00

7.35

5.27

17067

Ly6c

lymphocyte antigen 6 complex, locus C

0.99

1.12

1.00

6.03

5.77

17071

Ly6f

lymphocyte antigen 6 complex, locus F

0.80

0.89

1.00

5.66

5.01

20343

Sell

selectin, lymphocyte

0.61

0.79

1.00

5.03

3.91

76281

Tax1bp1

Tax1 (human T-cell leukemia virus type I) binding protein 1

1.01

1.51

1.00

5.02

1.98

230233

Ikbkap

inhibitor of kappa light polypeptide enhancer in B-cells

0.81

0.93

1.00

4.55

1.43

110454

Ly6a

lymphocyte antigen 6 complex, locus A

0.96

0.98

1.00

4.13

2.42

13025

Ctla2b

Cytotoxic T lymphocyte-associated protein 2 beta

0.68

1.20

1.00

4.12

3.40

71966

Nkiras2

NFKB inhibitor interacting Ras-like protein 2

1.07

1.27

1.00

3.80

1.93

17087

Ly96

lymphocyte antigen 96

1.13

1.43

1.00

3.77

1.44

17069

Ly6e

Lymphocyte antigen 6 complex, locus E

0.77

1.15

1.00

3.28

1.87

  1. * In italic transcripts common to day 21 and 42; in bold those unique to each category