Table 2 Transcripts up and down regulated in Plk4 heterozygous MEFs.
From: Gene expression patterns in heterozygous Plk4 murine embryonic fibroblasts
Upregulated Genes | |||||||
|---|---|---|---|---|---|---|---|
Cell Cycle | Gene ID | Fold Change | Putative p53 site | Metabolism | Gene ID | Fold Change | Putative p53 site |
Casein kinase II (Csnk2a1) | 12995 | 5.8040 | 20 | N-acylsphingosine amidohydrolase (acid ceramidase) like (Asahl) | 11886 | 6.0539 | 14 |
Protein phosphatase 1F (PP2C domain containing) (Ppm1f) | 68606 | 4.8644 | 10 | Leucyl/cystinyl aminopeptidase (Lnpep) | 240028 | 4.8539 | 6 |
Squamous cell carcinoma antigen recognized by T-cells 1 (Sart1) | 20227 | 4.6888 | 20 | Galactose-4-epimerase (Gale) | 74246 | 4.7700 | 8 |
Origin recognition complex, subunit 4-like (Orc4l) | 26428 | 4.5661 | 9 | L-2-hydroxyglutarate dehydrogenase (L2hgdh) | 217666 | 4.6257 | 15 |
Inhibitor of DNA binding 2 (Id2) | 15902 | 4.4323 | 11 | Fatty acid desaturase 3 (Fads3) | 286922 | 4.2976 | 27 |
Protein phosphatase 5 (Ppp5c) | 65179 | 4.0765 | 15 | Carbohydrate sulfotransferase 2 (Chst2) | 54371 | 4.2926 | 18 |
heme binding protein 2 (Hebp2) | 56016 | 3.8955 | 10 | Stearoyl-Coenzyme A desaturase 1 (Ankrd13c) | 433667 | 3.9806 | 16 |
Neuropilin (Nrp1) | 18186 | 3.0956 | 13 | CCR4 carbon catabolite repression like 4 (Ccrn4l) | 310395 | 3.7939 | 14 |
Prohibitin (Phb) | 18673 | 3.0459 | 18 | protein kinase, cAMP dependent regulatory, type I beta (Prkar1b) | 19085 | 3.3199 | 18 |
Cyclin dependent kinase 8 (Cdk8) | 264064 | 3.0094 | 17 | DNA Repair | |||
Heterogeneous nuclear ribonucleoprotein C (Hnrpc) | 15381 | 2.5962 | 8 | Uracil-DNA glycosylase (Ung) | 22256 | 4.1846 | 15 |
TVMSFG fibroblast growth factor receptor 1 precursor (Fgfr1) | 14182 | 2.2643 | 18 | MutS homolog 6 (Msh6) | 17688 | 2.1811 | 23 |
Phosphatidylinositol 3-kinase (Pic3c2a) | 18704 | 2.1636 | 9 | Thymine DNA glycosylase (Tdg) | 21665 | 2.0156 | 10 |
Pituitary tumor-transforming 1 (Pttg1) | 30939 | 1.9518 | 11 | Â | Â | Â | Â |
Development | Transcriptional/Translational Regulation | ||||||
Sal-like 3 (Sall3) | 20689 | 7.9335 | 13 | Cysteinyl-tRNA synthetase (Cars) | 27267 | 4.8072 | 18 |
T-cell factor 4 (Rab27b) | 80718 | 4.7804 | 14 | Zinc Finger Protein 451 (Zfp451) | 98403 | 4.1537 | 9 |
Nuclear receptor co-repressor 1 (Ncor1) | 20185 | 4.4658 | 16 | Tetratricopeptide repeat domain 1 (Ttc1) | 66827 | 4.0003 | 20 |
Inositol 1,4,5-triphosphate receptor 5 (Itpr2) | 16439 | 3.6909 | 10 | Highly similar to CBP_MOUSE CREB-binding protein (Crebbp) | 12914 | 3.7483 | 9 |
Procollagen, type VI, alpha 3 (Col6a3) | 12835 | 3.5828 | 15 | Zinc finger protein 689 (Zfp689) | 71131 | 3.4636 | 17 |
Fetal Alzheimer antigen (Bptf) | 207165 | 3.3594 | NA | Glutamyl-prolyl-tRNA synthetase (Eprs) | 107508 | 3.3065 | 19 |
WNT1 inducible signaling pathway protein 1 (Wisp1) | 22402 | 3.2886 | 22 | GC-rich sequence DNA-binding factor homolog isoform 1 (C21orf66) | 67367 | 3.0984 | N/A |
T-box transcription factor Tbx15 (Tbx15) | 21384 | 2.9248 | 13 | Phenylalanine-tRNA synthetase 2 (Fars2) | 69955 | 3.0678 | 13 |
Nuclear factor I/X (Nfix) | 18032 | 2.8883 | 9 | GLIS family zinc finger 3 (Glis3) | 226075 | 2.6233 | 10 |
Thrombospondin 2 (Thbs2) | 21826 | 2.5437 | 23 | Transmembrane and tetratricopeptide repeat containing 2 (Tmtc2) | 278279 | 2.2096 | 18 |
Osteopontin (Spp1) | 20750 | 2.4717 | 15 | Transcription factor A (Tfam) | 21780 | 2.0680 | 14 |
Fukuyama type congenital muscular dystrophy homolog (Fktn) | 246179 | 2.2362 | 9 | Â | Â | Â | Â |
DNA Methylation | Cellular/Ion Transport | ||||||
SAP30 binding protein (Sap30bp) | 57230 | 2.9834 | 8 | Pleckstrin (Plek) | 56193 | 6.0575 | 11 |
SET domain ERG-associated histone methyltransferase (Olfml3) | 99543 | 2.0889 | 9 | Syntaxin 18 (Stx18) | 53407 | 5.0970 | 18 |
Calcium binding and coiled coil domain 1 (Calcoco1) | 67488 | 5.6489 | 19 | Aquaporin-1 (Aqp1) | 11826 | 4.4128 | 16 |
| Â | Â | Â | Â | Solute carrier family 6 (Slc6a6) | 21366 | 4.4110 | 18 |
Miscellaneous Cellular Functions | Exocyst complex component 3 (Exoc3) | 211446 | 3.9296 | 10 | |||
Coiled Coil domain containing 131 (Ccdc131) | 216345 | 6.4372 | 11 | Protein-coupled receptor 19 (Gpr19) | 14760 | 3.8281 | 21 |
Thyroid hormone receptor interactor 11 (Trip11) | 109181 | 5.8691 | NA | Solute carrier family 39 (Slc39a10) | 227059 | 3.5028 | 13 |
Smg-6 homolog (Smg6) | 103677 | 5.3375 | 11 | Frequenin homolog (Freq) | 14299 | 3.1881 | 15 |
Talin 2 (Tln2) | 70549 | 5.2780 | N/A | Serine Hydrolase like (Serhl) | 68607 | 3.1718 | 17 |
Tomoregulin 1 (Tmeff1) | 230157 | 5.1116 | 7 | Solute carrier family 14 (Slc14a2) | 27411 | 3.0842 | 14 |
Channel-interacting PDZ domain protein (Inadl) | 12695 | 4.9504 | 14 | Translocator of inner mitochondrial membrane (Timm17b) | 21855 | 2.7129 | 19 |
WD repeat domain 50 (Utp18) | 217109 | 4.9252 | 16 | Similar to crooked neck protein (Ipo7) | 233726 | 2.5873 | 17 |
Inositol hexaphosphate kinase 1 (Ip6k1) | 27399 | 4.8086 | 12 | Oxysterol binding protein like protein 9 (Osbpl9) | 100273 | 2.5501 | 12 |
Spetex-2E protein (100040875) | Â | 4.6574 | N/A | ATPase, Ca++ transporting, plasma membrane 2 (Atp2b2) | 11941 | 2.4328 | 26 |
Multiple PDZ domain protein (Mpdz) | 17475 | 4.0596 | 12 | Transient receptor potential cation channel, subfamily M, member 7 (Trpm7) 58800 | Â | 1.9917 | 11 |
Myosin heavy chain 10 (Myh10) | 77579 | 3.8880 | 11 | Â | Â | Â | Â |
CDC42 effector protein (Rho GTPase binding) 2 (Cdc42ep2) | 104252 | 3.5581 | 23 | Downregulated Genes | |||
Zinc finger protein 507 (Zfp507) | 668501 | 3.4688 | N/A | Development | |||
aarF domain containing kinase 1 (Adck1) | 72113 | 3.4641 | 9 | Procollagen, type III, alpha 1 (Col3a1) | 12825 | -4.6364 | 6 |
AHNAK nucleoprotein (Ahnak) | 66395 | 3.2688 | 20 | Procollagen, type V, alpha 2 (Col5a2) | 12832 | -4.1420 | 12 |
Ring finger protein 11 (Arhgdia) | 192662 | 3.1199 | 25 | Oral-facial-digital syndrome 1 gene homolog (Ofd1) | 237222 | -3.0782 | 8 |
Villin (Vil1) | 22349 | 2.9808 | 15 | Procollagen, type I, alpha 2 (Col1a2) | 12843 | -2.9648 | 12 |
3-phosphoglycerate dehydrogenase (Phgdh) | 236539 | 2.9427 | 18 | Metabolism | |||
Arginine/serine-rich coiled-coil 1 (Rsrc1) | 66880 | 2.9404 | 6 | Stearoyl-Coenzyme A desaturase 2 (Scd2) | 20250 | -2.4729 | 10 |
Olfactory receptor 202 (Olfr202) | 258997 | 2.9278 | 7 | Mus musculus mVL30-1 retroelement mRNA sequence (mVL30-1) | Â | -2.5566 | N/A |
Discs, large homolog 5 (Dlg5) | 71228 | 2.9094 | N/A | Transmembrane protein 34 (Tmem184c) | 234463 | -2.5241 | 14 |
2'-phosphodiesterase (E430028B21Rik) | Â | 2.8426 | 0 | Mus musculus 0 day neonate cerebellum cDNA (E430024C06Rik) | 319443 | -2.3000 | N/A |
HD domain containing 3 (Hdcc3) | 68695 | 2.7345 | 14 | Hypothetical protein LOC639390 (LOC639390) | Â | -2.2121 | N/A |
Heat shock protein 1(Heatr1) | 217995 | 2.7243 | 13 | Â | Â | Â | Â |
Myotubularin related protein 7 (Mtmr7) | 54384 | 2.4370 | 8 | Â | Â | Â | Â |
Mitochondrial ribosomal protein L50 (Mrpl50) | 362517 | 2.2540 | 20 | Â | Â | Â | Â |
Proteasome(macropain)26S subunit, non-ATPase (Psmd4) | 19185 | 2.2031 | 11 | Â | Â | Â | Â |
NICE-5 protein (AA414768) | 245350 | 2.1272 | N/A | Â | Â | Â | Â |