Figure 8

Multi-way nutrimouse data set: MFA approach provides findings in accordance with those found by specialists. A and B. Individual factor maps show partition of the mice according to Diet and Genotype. Mice fed the COC diet (black circles and triangles) are separated from the other mice on PC1. PPARα deficient mice (triangles, PPAR) are separated from wild-type mice (circles, WT) on PC2. C. Variables representation. The genes and FAs most correlated to each principal components are named. Mice from both genotype displayed specific accumulations of FA families. Mice fed the SUN diet had enriched proportion of n-6 FAs, those fed the LIN and FISH diets are particularly related to n-3 FAs. Mice fed the COC diet preferentially accumulate mono-unsaturated FAs in their livers. Genes most correlated with PC2 are PPARα target genes (Peci, Cyp4a10, Cyp4a14, Acox1, Acaa1b, Hmgcs2, Cpt2) or genes involved in hepatic detoxification (Cyp3a11). D. Enriched GO terms (p-value < 0.05) are projected on the Groups scatter-plot, the most correlated to each PC are named. Annotations related to PC1 and PC2 are respectively linked to FA and glucose metabolism. The GO term 'cardiac muscle cell differentiation' (GO:0055007) is enriched by class II nuclear receptors (retinoid × receptors and retinoic acid receptors) which are also key regulators of lipid metabolism.