Simultaneous analysis of distinct Omics data sets with integration of biological knowledge: Multiple Factor Analysis approach

Table 2 Single data set: Genes strongly correlating with gliobastoma.

Gene Symbol	Gene Name	PC1
S100A11	S100 calcium binding protein A11	0.895
ANXA2	annexin A2	0.876
CLIC1	chloride intracellular channel 1	0.871
HEXB	hexosaminidase B (beta polypeptide)	0.868
MRC2	mannose receptor, C type 2	0.867
FRY	furry homolog (Drosophila)	-0.834
PHYHIPL	phytanoyl-CoA 2-hydroxylase interacting protein-like	-0.848
CLASP2	cytoplasmic linker associated protein 2	0.851
GLUD1	glutamate dehydrogenase 1	-0.855
MAPT	microtubule-associated protein tau	-0.874

The first 10 genes most strongly correlating with PC1 are shown with identifiers and corresponding coordinate. Among these ten genes, four are co-cited with 'glioma' on PubMed and five with 'cancer'. And the Ingenuity Pathway Analysis gives links between ANXA2, CLIC1, HEXB, MAPT and S100A11 in a network related to 'Cellular Movement, Cell-To-Cell Signaling and Interaction, Nervous System Development and Function'.

ISSN: 1471-2164