Simultaneous analysis of distinct Omics data sets with integration of biological knowledge: Multiple Factor Analysis approach

Table 3 Single data set: Gene Ontology terms highly associated with gliobastoma

Enrich. GO Identifier	Go Term	PC1
Cell cycle/Death
* GO:0016265	death	0.953
GO:0007049	cell cycle	0.958
* GO:0008219	cell death	0.956
* GO:0012501	programmed cell death	0.951
GO:0051726	regulation of cell cycle	0.941
* GO:0006915	apoptosis	0.965
GO:0000074	regulation of progression through cell cycle	0.921
* GO:0042981	regulation of apoptosis	0.923
GO:0045786	negative regulation of progression through cell cycle	0.904
GO:0007050	cell cycle arrest	0.912
Proliferative behavior
* GO:0051179	localization	0.986
* GO:0007154	cell communication	0.985
GO:0007155	cell adhesion	0.966
GO:0040011	locomotion	0.952
* GO:0051234	establishment of localization	0.985
GO:0007267	cell-cell signaling	0.954
GO:0007626	locomotory behavior	0.919
* GO:0008283	cell proliferation	0.917
GO:0051641	cellular localization	0.918
* GO:0042127	regulation of cell proliferation	0.916
* GO:0006928	cell motility	0.916
Development
GO:0007275	multicellular organismal development	0.984
GO:0009653	anatomical structure morphogenesis	0.955
* GO:0030154	cell differentiation	0.951
* GO:0048513	organ development	0.942
GO:0007399	nervous system development	0.943
* GO:0000902	cellular morphogenesis	0.926

The annotation are grouped by meaningful categories (Cell Cycle/Death; Invasive behavior and Development) and are ordered by GO depth. PC1 coordinates for each GO annotation is provided in the third column. These groups of annotations underline the well known characteristics of glioblastomas among other gliomas: a rapid progression with parenchyma invasion by isolated tumor cells sustained by cell cycle dysfunctions. It also emphasizes the existence of a relation from neurogenesis-related genes to gliobastoma. Enriched terms (p-value < 0.05) are marked with a star.

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