Table 1 Differentially regulated genes between mature and T1 immature B cells.
From: A Myc-regulated transcriptional network controls B-cell fate in response to BCR triggering
Gene symbol | Function | M/IM |
|---|---|---|
Syngr2 | B-cell and neuronal differentiation | 2.1 |
Idi1 | cholesterol synthesis | 1.7 |
Myc | B-cell proliferation, differentiation | 1.7 |
Litaf | regulates inflammatory cytokine expression | 1.5 |
Spag9 | positively regulates MAPK signaling pathways | 1.4 |
Rnf5 | inhibits cell motility | 1.4 |
Mfn2 | mitochondrial fusion | 1.3 |
Txnip | immune cell differentiation | 1.3 |
Mfap3 | no data | -1.3 |
Bnip3l | apoptosis | -1.3 |
Clta | intracellular protein transport | -1.5 |
Actb | cytoskeleton structure | -1.5 |
Pik3c2a | survival and proliferation | -1.6 |
Acad9 | mitochondrial fatty acid oxidation | -1.6 |
Prkcd | inhibits B-cell proliferation and differentiation | -1.6 |
Vezf1 | angiogenesis | -1.6 |
Pcyt1a | apoptosis | -1.7 |
Cecr2 | chromatin remodeling | -1.7 |
Zcchc17 | no data | -1.7 |
Coro1b | neurite outgrowth | -1.7 |
Atp5c1 | no data | -1.8 |
H2afz | embryonic development | -1.8 |
Cd24a | B-cell apoptosis; development of immature B cells | -2.1 |
Npc2 | cholesterol transport | -2.1 |
Emb | cell adhesion during development | -2.2 |
Fcgr2b | inhibits B-cell proliferation | -2.2 |
Emx2 | neuronal growth and development | -2.3 |
Cst3 | reduces antigen presenting capacity of dendritic cells | -2.3 |
Id2 | inhibits B-cell differentiation | -2.6 |
Cul7 | regulates B-cell differentiation | -2.6 |
Wwp1 | T-cell differentiation; embryogenesis | -2.7 |
Jun | apoptosis, proliferation, differentiation | -2.7 |
Ctsb | apoptosis | -2.8 |
Ifitm3 | inhibits proliferation | -3.1 |
Nr2f2 | regulates organogenesis | -3.1 |
Atp1b1 | inhibits T-cell activation | -3.2 |
Slc40a1 | iron export | -3.6 |
Phtf | regulates spermatogenesis | -3.7 |
Hoxb3 | regeneration of stem cells | -3.8 |
C1qa | reduces T cell-dependent immune response | -5.1 |
Laptm5 | B-cell differentiation; inhibits maturation of dendritic cells | -6.2 |
Hmox1 | inhibits B-cell activation; inhibits T-cell proliferation | -7.4 |
Hba-a1 | oxygen transport | -7.9 |
Lyzs | defense response to bacteria | -23.8 |