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Table 2 BCR-regulated genes discriminating immature and mature B cells at 2 h.

From: A Myc-regulated transcriptional network controls B-cell fate in response to BCR triggering

   microarrays qPCR
   BCR/ctrl   BCR/ctrl
Gene symbol Function IM M M/IM IM M
Ptger4 B-cell activation and differentiation 1.7 4.6 2.8 1.8 4.8
Marcksl1 proliferation, cell adhesion, neurosecretion 2.6 6.1 2.4 2.2 4.3
Myc B-cell proliferation, differentiation, apoptosis 3.8 8.9 2.3 4.1 12.9
Crsp9 proliferation 1.4 3.0 2.1 1.7 3.1
Chchd4 no data 1.6 3.3 2.1 1.7 3.1
Wdr55 rRNA synthesis, cell cycle progression 1.3 2.4 1.9 1.7 1.9
Ifrd1 differentiation, proliferation 1.3 2.2 1.7 1.4 2.3
Eif3s1 T-cell activation 1.3 2.3 1.7 1.7 2.0
Idi1 cholesterol synthesis 1.6 2.7 1.7 1.6 2.3
M6pr lysosomal enzyme transport 1.4 2.5 1.7 1.1 2.0
Nola2 T-cell activation 1.4 2.3 1.7 1.7 2.2
Pdhx electron transport 1.8 3.0 1.7 -1.3 -1.4
Hrb spermiogenesis 1.5 2.3 1.5 1.1 2.5
Lyar cell growth 1.3 1.9 1.5 1.2 2.7
Irx3 heart and CNS development -1.0 1.4 1.4 -1.2 1.5
Rpo1-3 cell growth 1.1 1.5 1.4 1.1 1.5
Ptdss1 cell growth -1.0 1.4 1.4 -1.4 1.4
Stt3b oligosaccharyltransferase activity 1.9 1.3 -1.5 2.6 -1.3
Plekha2 B-cell receptor signaling -1.7 -2.6 -1.6 -2.5 -5.4
Fbxo22 no data 1.0 -1.6 -1.6 -1.4 -2.0
Jun apoptosis, proliferation, differentiation 1.1 -1.6 -1.8 -1.1 -3.4
3110001A13Rik no data -1.7 -3.6 -2.1 -1.6 -5.1
Spata13 no data -1.8 -4.8 -2.7 -2.5 -16.7
Tmem23 apoptosis -1.9 -5.3 -2.8 -2.8 -20.0
  1. Differentially expressed genes in immature (IM) and mature (M) B cells at 2 h of BCR stimulation identified by two-way ANOVA (P < 0.05). Expression changes are shown as ratios of BCR triggered (BCR) versus control (ctrl) B cells at 2 h. Data are means of at least five replicate microarray experiments and at least two independent triplicate RT-PCR results.