Figure 3From: Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cellsRelating Module Membership to Epigenetic Regulation. The top 1000 genes with highest module membership in the black module (top row) and blue module (bottom row) are related to 3 epigenetic variables (corresponding to the 3 columns). The y-axis reports the proportion of top 1000 genes that are known to belong to the group of genes defined on the x-axis. Histone H3K4me3 trimethylation status is abbreviated K4, H3K27me3 trimethylation statys is abbreviated by K27. Promoters that are both H3K4 and H3K27 trimethilated in ES cells (denoted K 4&K 27) are thought to poise key developmental genes for activation upon differentiation [50, 51]. Note that genes with promoter CpG methylation are significantly (p = 2.0 × 10-14) under-enriched with respect to the top 1000 black module genes.Back to article page