Conserved domains in the Mutator protein MURA and its homologs are present in TvMULE1. A – Multiple sequence alignment of the conserved transposase domain. This alignment includes the MURA transposase from the Zea mays MuDR element (accession no. 540581), putative MURA-related transposases from the plants Zea mays (Zm-40034: accession no. 23928448, Jittery: accession no.7673677), Arabidopsis thaliana (AtMu1: accession no. AC002983.1 and At-96881: accession no. 34914922), Oryza sativa (Os-918808: accession no. 8777291), from the fungi Fusarium oxysporum (Hop-78: accession no. 30421204) and Yarrowia lipolytica (Mutyl: accession no. 50556866), and from the unicellular protozoan Trichomonas vaginalis (TvMULE1: deposited in Repbase). B – Multiple sequence alignment of the zinc finger domain. Identical amino acids are shaded in black, and similar amino acids are shaded in gray. The well-conserved D34E integrase signature in the active site of Mutator is noted. The symbol (dark filled triangles) below of the alignment corresponds to other residues also well conserved across a wide range of Mutator-like elements, previously described by Lisch .