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Table 2 Algorithm comparison for three methods

From: A stochastic model for identifying differential gene pair co-expression patterns in prostate cancer progression

Features Methods
  SIG method ECF method DAGA method
Measure of co-expression change z-CC ratio ECF-statistic z-CC ratio
Analytical distribution + - +
Progression consideration + - -
Multiple test analysis + - -
Gene specificity analysis + - -
Gene pair duple confirmation + + -
  1. The symbols '+' and '-' represent existence and absence of the corresponding categories. Because the distribution for each gene is different, gene pair duple confirmation refers to a gene pair (A, B) could be identified only when gene A is chosen, the pair shows significant co-expression change; meanwhile, when gene B is chosen, the pair is also determined with significant differential co-expression between two progressive stages.