Efficient yeast ChIP-Seq using multiplex short-read DNA sequencing

BMC Genomics

Table 7 ChIP-Seq simulations of depth of sequencing for three model organisms

		Fold Enrichment of Simulated Sites
	Genome Size (Mb)	5×	10×
C. elegans	100	2,400,000	800,000
D. melanogaster	123	3,500,000	1,000,000
A. thaliana	157	6,800,000	1,500,000

Number of reads required in order to identify greater than 95% of 1,000 simulated binding sites distributed over the genomes of C. elegans, D. melanogaster and A. thaliana for average fold enrichments of 5× and 10×. See Methods for details of the simulation.

ISSN: 1471-2164