Table 1 Genes in HCV associated pathways identified as regulated by miRNAs during HCV infection
Canonical pathways (IPA) | Predicted target genes | Number of targets |
|---|---|---|
Chemokine Signaling | SRC, CALM3, CALM2, MAPK6, PPP1CB, KRAS, LIMK2, PTK2, CAMK2D, RRAS2, MAPK14, CCL2, RHOA, CXCL12, CALM1, PRKCB | 16 |
B Cell Receptor Signaling | MAP2K4, MAP3K14, CALM3, PIK3R1, CALM2, MAPK6, KRAS, INPPL1, PTEN, BCL2L1, CAMK2D, RRAS2, MAPK14, BCL10, PAG1, LYN, PIK3AP1, CALM1, PRKCB | 19 |
PTEN Signaling | PIK3R1, MAPK6, INPPL1, KRAS, CCND1, PTEN, PTK2, BCL2L1, RRAS2, GHR, BMPR1A, CDKN1A, FASLG | 13 |
IL-6 Signaling | MAP2K4, IL6ST, MAP3K14, MAPK6, MAP4K4, KRAS, IL1R1, STAT3, COL1A1, IL1F9, RRAS2, MAPK14, MAPKAPK2 | 13 |
ERK/MAPK Signaling | RAP1B, SRC, PIK3R1, MAPK6, PPP1CB, KRAS, STAT3, PPP2R5A, DUSP2, EIF4E, PLA2G4C, YWHAQ, PTK2, MAPKSP1, RRAS2, ELF3, PRKCB, PRKAR1A | 18 |
JAK/Stat Signaling | RRAS2, PIK3R1, CDKN1A, SOCS6, MAPK6, KRAS, STAT3 | 7 |