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Table 1 HIGK gene ontology comparing P. gingivalis and S. gordonii co-infectionto P. gingivalis mono-infection.a

From: The degree of microbiome complexity influences the epithelial response to infection

Impacted pathwayb

Impact factorc

# of modulated genes (total) in Pathwayd

p-value

Cell cycle

13.542

45 (112)

< 0.001

Ubiquitin mediated proteolysis

11.305

22 (45)

< 0.001

Adherens junction

8.788

29 (77)

< 0.001

TGF-beta signaling pathway

7.989

29 (84)

0.002

SNARE interactions in vesicular transport

7.691

16 (36)

0.001

Apoptosis

7.513

30 (84)

0.002

Jak-STAT signaling pathway

6.989

46 (153)

0.003

MAPK signaling pathway

6.207

75 (273)

0.009

Wnt signaling pathway

5.208

42 (147)

0.02

Colorectal cancer

5.184

23 (77)

0.05

Notch signaling pathway

5.134

16 (46)

0.03

  1. aThe epithelial cell pathways were determined by Pathway Express.
  2. bKyoto Encyclopedia of Genes and Genomes pathways http://www.genome.jp/kegg/.
  3. cThe impact factor measures the pathways most affected by the changes in gene expression by considering the proportion of differentially regulated genes, the perturbation factors of all the pathway genes, and the propagation of these perturbations throughout the pathway. Only pathways with an impact factor greater than 5 are included.
  4. dNumber of regulated genes in a pathway/total number of genes currently mapped to this pathway.