TY - JOUR AU - Parisi, Fabio AU - Sonderegger, Bernhard AU - Wirapati, Pratyaksha AU - Delorenzi, Mauro AU - Naef, Felix PY - 2009 DA - 2009/08/18 TI - Relationship between estrogen receptor α location and gene induction reveals the importance of downstream sites and cofactors JO - BMC Genomics SP - 381 VL - 10 IS - 1 AB - To understand cancer-related modifications to transcriptional programs requires detailed knowledge about the activation of signal-transduction pathways and gene expression programs. To investigate the mechanisms of target gene regulation by human estrogen receptor α (hERα), we combine extensive location and expression datasets with genomic sequence analysis. In particular, we study the influence of patterns of DNA occupancy by hERα on expression phenotypes. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-10-381 DO - 10.1186/1471-2164-10-381 ID - Parisi2009 ER -