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Table 1 Serum parameters in TCPOBOP treated mice.

From: Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers

Treatment

Vehicle

TCPOBOP

Vehicle

TCPOBOP

Diet

Standard

Standard

1% cholesterol

1% cholesterol

Total cholesterol (mmol/L)

3.21 ± 1.52

1.91 ± 0.21*

4.09 ± 0.80*

2.67 ± 0.61#

LDL-cholesterol (mmol/L)

0.33 ± 0.05

0.12 ± 0.02*

0.68 ± 0.06*

0.34 ± 0.09#

HDL-cholesterol (mmol/L)

1.03 ± 0.05

0.81 ± 0.18*

1.76 ± 0.39*

1.46 ± 0.37

Total triglyceride (mmol/L)

0.54 ± 0.1

0.82 ± 0.12*

1.39 ± 0.43*

1.15 ± 0.25

Glucose (mmol/L)

9.67 ± 0.68

8.59 ± 1.73

12.1 ± 2.16*

10.45 ± 1.83#

  1. Serum parameters in mice fed either standard or 1% cholesterol diet and treated either vehicle or TCPOBOP. Each value represents mean ± SD of 6 mice per group. Student t-test was used for calculation of statistical significance (p < 0.05). *Statistical significance compared to vehicle treated group on standard diet. #Statistical significance compared to vehicle treated group on high-cholesterol diet.