Table 5 Gene annotation of differentially expressed genes
From: Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers
KEGG pathway | No of genes | Genes |
|---|---|---|
TCPOBOP in normal mouse liver | ||
Adipocytokine signaling pathway | 10 | Pck1 , Adipor1, Ppara , Mapk9 , Cpt1a , Slc2a1, Nfkbia , Stat3 , Adipor2 , Slc2a4 |
Metabolism of xenobiotics by cytochrome P450 | 8 | Cyp1a2, Cyp2b13, Cyp2b10, Cyp2c40 , Cyp2e1 , Cyp2b9, Cyp3a25, Cyp3a13 |
PPAR signaling pathway | 7 | Pck1 , Cyp8b1 , Ppara , Apoa5 , Cpt1a , Cyp27a1, Pparg |
ABC transporters – General | 6 | Abcc2, Abcb11, Abca1 , Abcc1 , Abcb4 , Abcc3 |
Complement and coagulation cascade | 6 | Hc , C2 , C4bp , Serping1 , C9 , Fgb |
Insulin signaling pathway | 5 | Pck1, Fasn, Mapk9, Ppp1r3c, Slc2a4 |
Arachidonic acid metabolism | 5 | Cyp2b13, Cyp2b10, Cyp2c40 , Cyp2e1 , Cyp2b9 |
Linoleic acid metabolism | 5 | Cyp1a2, Cyp2c40 , Cyp2e1 , Cyp3a25, Cyp3a13 |
Biosynthesis of steroids | 4 | Lss, Sqle, Hmgcr, Sc5d |
Cholesterol diet | ||
Biosynthesis of steroids | 13 | Dhcr7 , Lss , Mvk , Nsdhl , Idi1, Cyp51a1 , Sqle , Hmgcr , Mvd , Fdps , Fdft1 , Dhcr24 , Sc4mol |
Metabolism of xenobiotics by cytochrome P450 | 4 | Cyp2f2, Cyp2c40, Cyp3a25 , Cyp3a13 |
PPAR signaling pathway | 4 | Ppara, Scd1, Scp2, Apoc3 |
Terpenoid metabolism | 4 | Idi1, Sqle , Fdps , Fdft1 |
TCPOBOP in hyperlipidemic mouse liver | ||
Biosynthesis of steroids | 10 | Lss, Mvk, Nsdhl, Cyp51a1, Hmgcr, Mvd, Fdps, Fdft1, Dhcr24, Sc4mol |
PPAR signaling pathway | 7 | Pck1 , Cyp8b1 , Ppara , Apoa5 , Scd1 , Cpt1a , Cyp27a1 |
Metabolism of xenobiotics by cytochrome P450 | 7 | Cyp1a2, Cyp2b13, Cyp2b10, Cyp2c40 , Cyp2b9, Cyp3a25, Cyp3a13 |
Adipocytokine signaling pathway | 6 | Pck1 , Ppara , Cpt1a , Slc2a1, Adipor2 , Mapk8 |
Arachidonic acid metabolism | 6 | Cyp2b13, Cyp2b10, Cyp2c40 , Cyp2b9, Cyp4f14 |
ABC transporters – General | 5 | Abcg5 , Abcc2, Abca1 , Abcc3, Abcg8 |
Linoleic acid metabolism | 5 | Pla2g6, Cyp1a2, Cyp2c40 , Cyp3a25, Cyp3a13 |
Complement and coagulation cascade | 5 | C2 , C4bp , Serping1 , C9 , Fgb |
Butanoate metabolism | 4 | Hmgcl, Hmgcs1, Acat2 , Pdhb |