Figure 5

Probes showing differential expression between normal and tumor regions. Differential expression between normal and tumor regions is plotted with log-scaled P value according to Student's t-test for sense (x-axis) and antisense (y-axis) expression. In cases where the mean value of signals from normal regions was higher than that of tumors, the value was multiplied by -1. Accordingly, values higher than zero indicate up-regulation, whereas values lower than zero indicate down-regulation, in tumors. (A) Colored points denote significant changes in the expression of both the sense and antisense transcripts in tumors, in a correlated manner (blue) and in an anti-correlated manner (red). The names of the genes indicated by the colored points are listed in additional file 6. (B) Orange and green dots indicate up-regulated and down-regulated antisense expression from genes, respectively, but no apparent changes in sense transcript expression.