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Table 3 Impact of hypoxia on genes regulated by NO.

From: Hypoxic transcription gene profiles under the modulation of nitric oxide in nuclear run on-microarray and proteomics

Symbol

Gene Name

Ac

NO

Hyp + NO

Ddit4

DNA-damage-inducible transcript 4

NM_029083.1

5.19

35.21

Trib3

tribbles homolog 3 (Drosophila)

NM_144554.1

5.85

27.11

Bnip3

BCL2/adenovirus E1B 19 kDa-interacting protein 1, NIP3

NM_009760.2

2.53

20.06

Phlda3

pleckstrin homology-like domain, family A, member 3

NM_013750.1

3.88

9.41

Nqo1

NAD(P)H dehydrogenase, quinone 1

U12961.1

2.99

8.32

Atf3

activating transcription factor 3

NM_007498.2

2.37

7.26

Vegfa

vascular endothelial growth factor A

NM_009505.2

2.06

6.55

Sesn2

sestrin 2

NM_144907.1

3.47

5.23

Adh7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

NM_009626.2

2.71

5.06

Gpt2

glutamic pyruvate transaminase (alanine aminotransferase) 2

NM_173866.1

2.49

5.02

Slc7a11

solute carrier family 7 (cationic amino acid transporter, y+ system), member 11

NM_011990.1

2.68

4.74

Cdkn1a

cyclin-dependent kinase inhibitor 1A (P21)

NM_007669.2

2.07

4.25

Scd1

stearoyl-Coenzyme A desaturase 1

NM_009127.2

4.18

3.55

Sfrs1

splicing factor, arginine/serine-rich 1 (ASF/SF2)

NM_173374.2

2.82

3.42

Slc19a2

solute carrier family 19 (thiamine transporter), member 2

NM_054087.1

2.32

3.08

Atp6ap2

ATPase, H+ transporting, lysosomal accessory protein 2

NM_027439.2

2.31

2.62

Txndc1

thioredoxin domain containing 1

NM_028339.1

2.03

2.58

Adam10

a disintegrin and metalloprotease domain 10

NM_007399.1

2.07

2.55

Lss

lanosterol synthase

AK012813.1

2.12

2.48

Pmaip1

phorbol-12-myristate-13-acetate-induced protein 1

NM_021451.1

2.27

2.46

Eif4g2

eukaryotic translation initiation factor 4, gamma 2

NM_013507.2

2.16

2.45

Sgpp1

sphingosine-1-phosphate phosphatase 1

NM_030750.2

3.00

2.42

Rbl2

retinoblastoma-like 2

NM_011250.2

2.01

2.33

D4Ertd765e

DNA segment, Chr 4, ERATO Doi 765, expressed

NM_026728.1

2.91

2.30

Vcl

vinculin

NM_009502.3

2.02

2.22

Pabpc1

poly A binding protein, cytoplasmic 1

NM_008774.2

2.11

2.19

Golph3

golgi phosphoprotein 3

NM_025673.2

2.18

2.15

Rrm1

ribonucleotide reductase M1

NM_009103.2

2.97

2.11

Nsmaf

neutral sphingomyelinase (N-SMase) activation associated factor

NM_010945.1

2.43

2.05

Dirc2

disrupted in renal carcinoma 2 (human)

NM_153550.2

2.23

2.03

Crip1

cysteine-rich protein 1 (intestinal)

NM_007763.1

-2.13

-2.09

Trerf1

transcriptional regulating factor 1

NM_172622.1

-2.14

-2.12

Rps19

ribosomal protein S19

NM_023133.1

-2.04

-2.18

Son

Son cell proliferation protein

NM_178880.3

-2.06

-2.23

Idb1

inhibitor of DNA binding 1

NM_010495.1

-2.45

-2.36

Nnt

nicotinamide nucleotide transhydrogenase

AK087064.1

-2.04

-2.41

Dhrs6

dehydrogenase/reductase (SDR family) member 6

NM_027208.1

-2.60

-2.42

Lst1

leukocyte specific transcript 1

NM_010734.1

-2.26

-2.55

Hps6

Hermansky-Pudlak syndrome 6

NM_176785.1

-4.86

-4.21

Fxyd5

FXYD domain-containing ion transport regulator 5

BC031112.1

-18.27

-9.71

  1. This list of 40 genes was obtained by comparing the NO (0.5 mM DETA-NO)-generated gene profile to that generated by hypoxia (1% O2) plus NO. Hyp = hypoxia treatment; NO = nitric oxide treatment.