Figure 2

Comparative analyses of WNT4 proximal promoter in tammar and human. Tammar and human WNT4 proximal promoter sequences and common potential transcription factors including TF modules are identified. They share the same minimal promoter characteristics, indicating similar mechanisms initiate WNT4 transcription and regulate its expression in both species. The potential putative transcription factors were labelled under their corresponding sequence. The red "ATG" indicated the start codon. The left arrow represents the DNA strand (-) of transcription factor binding site. The right arrow stands for the DNA strand (+) of transcription factor binding site. Core-search identified 4 core motifs located within the promoter region. TCGGCCC (black line) represents highly conserved motif 1; CTCCGGC (double blue line) stands for motif 2; GCTGGCC (dotted line) is motif 3;TGCGCTG (red line) is motif 4.