Genome-wide expression profiling of in vivo- derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei

Table 2 Enrichment or reduction of GO groups with respect to stumpy forms

Comparison	Enriched with respect to Stumpy	Reduced with respect to Stumpy
Slender relative to T0	protein-DNA complex assembly, various other chromatin-related terms	anion channel activity
T1 relative to T0	RNA transport, translation regulation	endonuclease activity
T6 relative to T0	translation, signalling, calmodulin binding, hexose transport	cell adhesion
T18 relative to T0	oxido-reductase activity	cell signalling (cyclase activity)
T48 relative to T0	trans-splicing, translation	anion channel activity

Enrichment of particular GO groups were assessed, using a hypergeometric test, to determine whether the GO terms attached to each individual gene were overrepresented relative to all genes (and their associated GO terms) present on the arrays. The enrichment of GO terms in genes up- and down-regulated during different periods of differentiation are shown.

ISSN: 1471-2164