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Table 1 Genes induced by cationic antimicrobial peptides.

From: Transcriptome analysis of the responses of Staphylococcus aureus to antimicrobial peptides and characterization of the roles of vraDE and vraSR in antimicrobial resistance

Gene ID

Gene name*

Induction with**

Known regulation***

Protein/Similarity

  

T

O

D

  

SA0011

 

3.5

2.1

  

Similar to homoserine-o-acethyltransferase

SA0122

butA

3.2

2.1

 

VCM

Acetoin reductase

SA0205

 

17.2

11.2

6.2

VCM

Similar to lysostaphin precursor

SA0344

metE

4.5

2.3

 

VCM

5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase

SA0428

 

3.6

2.4

2.3

 

Hypothetical protein

SA0430

gltB

4.4

2.5

  

Glutamate synthase large subunit

SA0480

ctsR

4.2

4.2

  

Transcription repressor of class III stress genes homologue

SA0513

 

3.3

2.2

  

Conserved hypothetical protein

SA0591

 

3.0

3.3

2.1

VCM

Hypothetical protein

SA0677

 

3.6

2.1

 

VCM

Similar to choline transport ATP-binding protein

SA0781

 

3.1

2.1

  

Similar to 2-nitropropane dioxygenase

SA0817

 

5.0

2.7

  

Similar to NADH-dependent flavin oxidoreductase

SA0825

spsA

2.6

3.5

2.0

VraSR, VCM

Type-1 signal peptidase

SA0835

clpB

3.9

4.1

 

VCM

ClpB chaperone homologue

SA0845

oppB

4.3

2.0

 

VCM

Oligopeptide transport system permease protein

SA0903

 

2.1

4.1

2.6

 

Conserved hypothetical protein

SA1164

dhoM

5.2

2.8

 

VCM

Homoserine dehydrogenase

SA1170

katA

4.3

2.6

  

Catalase

SA1216

 

3.8

2.4

  

Similar to oligoendopeptidase

SA1219

  

5.4

4.2

 

Similar to phosphate ABC transporter

SA1227

dapA

8.3

9.6

 

VCM

Dihydrodipicolinate synthase

SA1254

 

3.1

3.5

 

VraSR, VCM

Hypothetical protein

SA1476

 

4.2

5.3

3.3

VraSR, VCM

Hypothetical protein

SA1517

citC

4.9

5.8

3.1

VCM

Isocitrate dehydrogenase

SA1545

serA

4.6

2.5

 

VCM

Similar to soluble hydrogenase 42 kD subunit

SA1549

htrA

2.9

3.0

2.0

VraSR, VCM

Similar to serine proteinase Do, heat-shock protein HtrA

SA1599

 

3.2

2.4

  

Similar to transaldolase

SA1655

ecsA

3.0

3.0

  

ABC transporter EcsA homologue

SA1659

prsA

3.2

4.5

2.9

VraSR, VCM

Peptidyl-prolyl cis / trans isomerase homologue

SA1701

vraS

3.9

5.3

2.5

VraSR, VCM

Two-component sensor histidine kinase

SA1820

 

3.6

3.0

2.2

 

Similar to bacteriophage terminase small subunit

SA1836

groEL

3.8

4.3

2.2

 

GroEL protein

SA1862

leuA

13.5

3.3

2.1

 

2-isopropylmalate synthase

SA1990

 

3.4

2.6

2.2

 

Conserved hypothetical protein

SA2113

 

2.2

3.7

2.2

VraSR, VCM

Hypothetical protein

SA2221

 

2.4

3.2

 

VraSR, VCM

Hypothetical protein

SA2304

fbp

4.8

2.4

 

VCM

Fructose-bisphosphatase

SA2324

 

4.9

2.6

2.0

 

Similar to thioredoxin

SA2343

 

4.3

4.3

2.7

VraSR, VCM

Hypothetical protein

SA2397

 

3.5

2.3

 

VCM

Similar to pyridoxal-phosphate dependent aminotransferase

SA2467

hisH

40.1

4.3

 

VCM

Amidotransferase HisH

SA2492

vraD

8.2

32.4

17.2

VCM

Similar to ABC transporter

SAS016

 

5.0

7.4

5.4

VCM

Hypothetical protein

  1. *: Only the most strongly upregulated genes, the marker genes of the CAMP stimulon, are shown in this table. The complete list of genes induced at least 2-fold by several CAMPs is shown in additional file 1. In the case of operons, only the first gene or the most strongly induced gene is shown;
  2. **: T, temporin L-NH2; O, ovispirin-1-NH2; D, dermaseptin K4-S4(1-16)-NH2;
  3. ***: VCM, vancomycin inducible; VraSR, belongs to the VraSR regulon.
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BMC Genomics

ISSN: 1471-2164

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