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Table 4 Induction of vraD, SA0205, prsA and groEL in S. aureus ΔvraSR and ΔvraDE mutants treated with vancomycin.

From: Transcriptome analysis of the responses of Staphylococcus aureus to antimicrobial peptides and characterization of the roles of vraDE and vraSR in antimicrobial resistance

Mutant

Fold induction*

 

Gene

 

vraD

SA0205

prsA

groEL

ΔvraSR

7.9 (0.2)

2.5 (0.2)

3.2 (0.1)

2.1 (0.1)

ΔvraDE

not expressed

60.4 (2.1)

36.0 (0.7)

3.1 (0.4)

wild type

6.6 (0.6)

25.5 (1.8)

32.7 (1.7)

1.9 (0.0)

  1. *: The ratio of the expression level of the gene in the mutant or the wild-type strain treated for 10 minutes with 5 μg/ml of vancomycin to that in untreated cells as determined by qRT-PCR. The induction ratios are means from three experiments. Standard deviations are in parenthesis.
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