Reciprocal regulation by the CepIR and CciIR quorum sensing systems in Burkholderia cenocepacia

BMC Genomics

Table 1 Comparison of genes (or operons) showing differential expression in microarray analysis and previously determined to be CepIR regulated using transcriptional fusions.

Gene	Function^a	Change (fold) for K56-dI2 (cepI) vs K56-2	Change (fold) for K56-R2 (cepR) vs K56-2	Change (fold) for K56-2cciR vs K56-2	Change (fold) for K56-2cepRcciIR vs K56-2
		Promoter fusion^b	Microarray^c	Microarray^c	Microarray^c
BCAL0111	putative TPR domain	-3.7	-2.2	NC	-2.2
BCAL0380	ABC transporter ATP-binding subunit	-2.7	-2.3	NC	NC
BCAL0812	sigma 54 modulation protein	-2.0	-2.8	NC	NC
BCAL1814^d	MerR family regulatory protein	2.2	-2.9	-2.7	NC
BCAL1990	glucose-6-phosphate isomerase Pgi	-2.2	-2.6	NC	NC
BCAL2244	urocanate hydratase HutU	-2.2	-2.1	NC	NC
BCAL2931^d	radical SAM superfamily protein	3.2	2.0	NC	NC
BCAL3006^d	cold shock-like protein CspA	-1.9	-5.6	2.8	-4.9
BCAS0221	ABC transporter ATP-binding protein AfcB (pseudogene)	-1.7	-3.6	2.9	NC
BCAS0409	zinc metalloprotease ZmpA	-2.6	-5.3	4.0	-4.5

^aFunction derived from B. cenocepacia J2315 [34].
^cChange in 16-h cultures of cepI mutant compared to 16-h cultures of K56-2 as determined by promoter fusion Subsin et al. 2007 [27].
^cChange in 16-h cultures of cepR, cciR or cepRcciIR mutants compared to 16-h cultures of K56-2 as determined by microarray analysis with at least two biological replicates (NC, no change).
^dPresence of a cep box motif was identified by Subsin et al. 2007 [27] for this gene.

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