Table 3 Ingenuity Pathways Analysis: Top Bio Functions - Molecular and Cellular Functions

Protein Synthesis

3.67E-07 to 3.06E-02

MME, RPL22, UBE2H (includes EG:7328), RPL27A, LIF, RPL29, MMP14, RPL31, RPL14, IDE, NFKB1, EIF4EBP1, CASP9, TRHDE, RPL18A, EDN1, CTSS, MRP63, EIF5, RPS3, RPL18, MMP1 (includes EG:4312), RPL13, SRC, RRBP1, PJA1, EIF3H, RPL3, RPL34, C9ORF3, RPS2, APAF1, CEBPB, DCTN2, RPS12, KIAA0368, RPL15, WARS, RPL28, USE1, SGSM3, IFT52, SMURF2, PLAU

44

Cell Death

1.78E-04 to 3.06E-02

LIF, ATXN1, NME2, CDKN2C, TMEM132A, ARG2, MSX2, RBP1, PTEN, SOD2, CASP9, CCNB1IP1, CTSS, PQBP1, SUB1, NUPR1, FOSL2, BIRC3, HLA-C, FBL, NOX4, RP5-886K2.1, NOVA1, YWHAE, SGCG, MITF, FGFR1, THRA, JUNB, NFKB2, NDN, ADI1, OGG1, CCND2, RAPGEF2, BTG2, PRKACA, RUNX1, CYLD, LRIG1, MME, BRD2, GABPB2, ICAM1, RGS3, MMP14, KLF10, BMP2, SAT1, EXT1, DUSP22, TNFAIP3, FKBP1A, FNTA, NFKB1, QARS, ASNS, RPLP0 (includes EG:6175), COMP, EIF4EBP1, PGF, RASSF1, ANGPTL4, NFKBIA, EDN1, FOXO3, ACTC1, MMP1 (includes EG:4312), ATN1, B4GALT5, MUC1, CALR, SRC, PXN, PRMT2, THG1L, PPIF, BGN, ELL, APAF1, PPP1R15A (includes EG:23645), CEBPB, CLCF1, IGF2R, PRG2 (includes EG:5553), NUP62, MAFB, CTH, PLAU, ATP2B4

90

Cellular Development

2.14E-04 to 3.06E-02

LIF, NME2, SFPQ, MSX2, EEF1D, LIMK1, PTEN, SERPINB2, NR4A3, CDON, POSTN, NUPR1, FOSL2, NOX4, NAB1, MITF, FGFR1, THRA, L1CAM, NFKB2, MBD2, JUNB, NDN, CCND2, BTG2, RUNX1, MAST2, MSC, ICAM1, NLGN1, MMP14, BMP2, KLF10, MCC, METTL8, TNFAIP3, EXT1, NFKB1, PGF, RASSF1, NFKBIA, EDN1, FOXO3, ATN1, MMP1 (includes EG:4312), SRC, NHEJ1, CALR, PXN, RELB, ELL, APAF1, IRAK3, CEBPB, IGF2R, CLCF1, AFF1, RBPJ, MAFB, PLAU

60

Lipid Metabolism

2.41E-04 to 3.06E-02

MUC1, SRC, CASP9, EDN1, APAF1, PHGDH, FAR2, ABCA1, PTEN

9

Molecular Transport

2.41E-04 to 3.06E-02

CACNA1G, CALR, SRC, YWHAE, ATXN1, NUP133, SAT1, APAF1, NUP50, ABCA1, CASP9, EDN1, SMG7, PHGDH, ATP2B4

15