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Table 2 Highly represented protein functions in Tardigrades (COGs and KOGs).

From: Tardigrade workbench: comparing stress-related proteins, sequence-similar and functional protein clusters as well as RNA elements in tardigrades

Information from COG clusters1:

Information storage and processing

75 Translation elongation factor EF-1 (COG5256)

64 GTPases - translation elongation (COG0050)

58 Peptide chain release factor RF-3 (COG4108)

Cellular processes and signaling

31 Ubiquitin (COG5272)

25 Membrane GTPase LepA (COG0481)

21 Cysteine protease (COG4870)

Metabolism

75 Heme/copper-type cytochrome/quinol oxidases (COG0843)

67 GTPases - Sulfate adenylate transferase (COG2895)

Poorly characterized

11 Dehydrogenases with different specificities (COG1028)

11 Uncharacterized homolog of Blt101 (COG0401)

Information from KOG clusters1:

Information storage and processing

77 Translation elongation factor EF-1 (KOG0052)

71 Polypeptide release factor 3 (KOG0459)

70 Elongation factor 1 alpha (KOG0458)

53 Mitochondrial translation elongation factor Tu (KOG0460)

Cellular processes and signaling

52 Glutathione S-transferase (KOG1695)

46 Cysteine proteinase Cathepsin L (KOG1543)

34 Apolipoprotein D/Lipocalin (KOG4824)

31 Cysteine proteinase Cathepsin F (KOG1542)

Metabolism

78 Cytochrome c oxidase (KOG4769)

74 Fatty acid-binding protein FABP (KOG4015)

Poorly characterized

31 Ubiquitin and ubiquitin-like proteins (KOG0001)

16 GTPase Rab18, small G protein superfamily (KOG0080)

15 Ras-related GTPase (KOG0394)

15 GTPase Rab21, small G protein superfamily (KOG0088)

  1. 1 Detailed data and all COG/KOG numbers are given on the WEB page http://waterbear.bioapps.biozentrum.uni-wuerzburg.de/cgi-bin/cog_stat.pl. Summarized here are the functions of those clusters of orthologous groups (COGs) occurring particularly often or suggesting tardigrade specific adaptations.