The l1-l2 regularization framework unmasks the hypoxia signature hidden in the transcriptome of a set of heterogeneous neuroblastoma cell lines

Table 2 Hypoxia signature

probeset¹⁾	Gene Name	GenBank²⁾	f%³⁾	Description	References⁴⁾
201848_s_at	BNIP3	U15174	100	BCL2/adenovirus E1B 19 kDa interacting protein 3	[49]
202887_s_at	DDIT4	NM_019058	100	DNA-damage-inducible transcript 4	[49]
226452_at	PDK1	AU146532	100	pyruvate dehydrogenase kinase; isoenzyme 1	[63]
236180_at	-	W57613	100	Transcribed locus, hypothetical protein FLJ11267	-
223193_x_at	E2IG5	AF201944	94	growth and transformation-dependent protein	[50]
225342_at	AK3L1	AK026966	94	adenylate kinase 3-like 1	[4]
224345_x_at	E2IG5	AF107495	89	growth and transformation-dependent protein	[50]
202022_at	ALDOC	NM_005165	78	aldolase C; fructose-bisphosphate	[63]
210512_s_at	VEGF	AF022375	78	vascular endothelial growth factor	[4, 63]
201849_at	BNIP3	NM_004052	61	BCL2/adenovirus E1B 19 kDa interacting protein 3	[49]
235850_at	WDR5B	BF434228	50	WD repeat domain 5B	[64]

^a)Probesets selected for frequency = 50% and ε = 100. ^b)GenBank accession number. ^c)Selection frequency in leave-one-out cross-validation. ^d)Representative references describing the induction of the correspondent gene by hypoxia

ISSN: 1471-2164