Figure 1

Α-gliadin sequence with the position of CD-epitopes. The sequence of a mature α-gliadin protein (gi|7209265|emb|CAB76964.1, Triticum aestivum) with the location of the respective epitopes for celiac disease depicted. p31-49, PGQQ QPFPP Q QP YPQPQPF, triggering the innate immune response, the HLA-DQ2+ restricted T-cell epitopes Glia-α9(αI)(PFPQPQ LPY), Glia-α9(αIII), (PYPQPQ LPY), Glia-α2(αII) (PQPQ LPYPQ) and Glia-α20 (FRPQ QPYPQ) and the HLA-DQ8+ restricted T-cell epitope Glia-α (QGSFQPSQQN). Underlined Q is deamidated in the intestine by tTG.