| Â | Human | Chimp | Mouse | Rat | Chicken | Zebrafish | Pufferfish | Fruitfly | Worm |
|---|
HK | 1/0 [4] | 1/2 | 0/1 [3] | - [3] | 0/2 | - | - | - | - |
GPI | - [1] | - | 1/0 [1] | - [1] | - | - | - | - | - |
PFK | - [3] | - | - [3] | - [3] | - | 0/1 | - | - | - |
ALDO | 1/1 [3] | 1/1 | 11/0 [2] | 7/0 [3] | 0/1 | - | - | - | - |
TPI | 3/0 [1] | 2/1 | 6/1 [1] | 3/1 [1] | - | - | - | - | - |
GAPDH | 60/2 [2] | 47/3 | 285/46 [2] | 329/35 [2] | 0/1 | - | - | - | - |
PGK | 1/1 [2] | 1/2 | 2/0 [2] | 12/0 [1] | - | - | - | - | - |
PGM | 12/0 [2] | 13/1 | 9/0 [2] | 3/0 [2] | - | - | - | - | - |
ENO | 1/0 [3] | 1/2 | 12/1 [3] | 36/3 [3] | - | - | - | - | - |
PK | 2/0 [2] | 3/0 | 10/3 [2] | 4/1 [1] | - | - | - | - | - |
LDH | 10/2 [3] | 9/1 | 27/7 [3] | 25/4 [3] | - | - | - | - | - |
Total
|
97
|
91
|
422
|
463
|
4
|
1
|
0
|
0
|
0
|
- Numbers of pseudgenes (processed/duplicated) and [known parent gene isozymes] for each glycolytic enzyme. The numbers of known parent gene isozymes are shown only for human, mouse, and rat because they constitute the most completely annotated genomes in ENSEMBL. A dash '-' indicates that there are no processed or duplicated pseudogenes derived from a particular enzyme in a particular vertebrate genome. The chicken, zebrafish, pufferfish, fruitfly, and worm genomes contain very few or no pseudogenes, the human and chimpanzee genomes a moderate number, and the mouse and rat genomes significantly more. The pseudogene copy number for GAPDH far outnumbers those of any other glycolytic enzyme. Abbreviations: HK, hexokinase; GPI, glucose-6-phosphate isomerase; PFK, 6-phosphofructokinase; ALDO, aldolase; TPI, triose-phosphate isomerase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; PGK, phosphoglycerate kinase; PGM, phosphoglycerate mutase; ENO, enolase; PK, pyruvate kinase; LDH, lactate dehydrogenase.
