Figure 2
From: The theory of discovering rare variants via DNA sequencing
Gibbs' scenario [17]of using a fixed 2,000 unit sample size to discover extremely rare alleles, ϕ = 0.0005, under N = 1 and τ = 2. This hypothetical project is plotted for 5,000 ≤ R ≤ 100,000 and shows the conspicuous "stalling" effect that occurs under increasingly non-optimal conditions.