Skip to main content

Advertisement

Table 1 D. melanogaster serpins and Drosophilid orthologues

From: Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes

mel CG P1/P1' Signal Peptide Intron No. sim sec yak ere ana pse per wil moj vir gri
Spn27A 11331 K/F + 0 H H H H H H H H H H H
Spn28B 6717 K/K - 1 H H H H        
Spn28Da 31902 L/S - 0 H H H WH        
Spn28Db 33121 - - 1 H H H H        
Spn28Dc 7219 S/G + 1 H H H H H H H H H H H
Spn28F 8137 Y/S + 3 S   L H KS H E       
Spn31A 4804 - - 3 H H H H H H H H H H H
Spn38F 9334 K/S + 3            
Spn42Da 9453 A/S R/A T/S V/A +/- >3 H S H H H HS HS H H H H
Spn42Db 9454 K/G - 2 RHS RHS FHY RHS RSS RSS RSS S ESM RSS RSS
Spn42Dc 9455 M/M - 2 H S H H H HS HS H SS SS SS
Spn42Dd 9456 R/A + 3 S S L H S S SS SS ISR     
Spn42De 9460 E/S + 3 H H H H H H H SL    
Spn43Aa 12172 M/S + 3 H H H H H H H H H H H
Spn43Ab 1865 - + 3 H S H H H H H H H H H
Spn43Ac 1857 L/S + 2 H H H H H H H H HL H H
Spn43Ad 1859 - + 2 H S H H H H H   H H H
Spn47C 7722 - - 2 H H H H H S S S S S S
Spn53F 10956 - + 0 H H H H H       
Spn55B 10913 R/M - 1 H H H H H H H H H H H
Spn75F 32203 - - 4 H H H H        
Spn76A 3801 - + 1 S S S         
Spn77Ba 6680 K/A + >4 H H H H H H H H HS HS HS
Spn77Bb 6663 - - 3 S           
Spn77Bc 6289 - + 3 S H H         
Spn85F 12807 - + 1 H H H S H H H H H H H
Spn88Ea 18525 S/A + 2 H H H H H H H H H H H
Spn88Eb 6687 S/S + 2 HA HA HA HA        
Spn100A 1342 - + 1 H H H H H H H H H H H
  1. D. melanogaster serpins are identified by cytological location and FlyBase CG number. The putative proteinase cleavage sites (P1/P1') of inhibitory serpins are indicated in single-letter amino acid code. Putative extracellular serpins are distinguished by presence of an export signal peptide. Drosophilid species are arranged from left to right in order of increasing evolutionary separation from D. melanogaster: melanogaster sub-group (simulans, sechellia, yakuba, erecta), melanogaster group (ananassae), obscura group (pseudoobscura, persimilis), willistoni group (willistoni); repleta group (mojavensis), virilis group (virilis) and the Hawaiian group (grimshawi). Serpin orthologues were identified by homology (H) or synteny (S) to D. melanogaster transcripts. Three additional orthologues identified by homology, using the complete set of Drosophilid serpin transcripts as queries, are in italic typeface (H). The putative P1/P1' residues of inhibitory serpins are conserved within orthologous transcripts except were indicated by superscripts, left of symbol for P1 substitutions (KS), right of symbol for P1'substitutions (HS). Note that the Spn42Da transcript in melanogaster has alternatively spliced 3' and 5' exons, allowing 4 different RCL sequences to be attached to the same serpin core, either with, or without, a signal peptide. Two orthologues of melanogaster Spn28F were identified in ananassae.