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Table 1 D. melanogaster serpins and Drosophilid orthologues

From: Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes

mel

CG

P1/P1'

Signal

Peptide

Intron No.

sim

sec

yak

ere

ana

pse

per

wil

moj

vir

gri

Spn27A

11331

K/F

+

0

H

H

H

H

H

H

H

H

H

H

H

Spn28B

6717

K/K

-

1

H

H

H

H

       

Spn28Da

31902

L/S

-

0

H

H

H

WH

       

Spn28Db

33121

-

-

1

H

H

H

H

       

Spn28Dc

7219

S/G

+

1

H

H

H

H

H

H

H

H

H

H

H

Spn28F

8137

Y/S

+

3

S

 

L H

KS

H E

      

Spn31A

4804

-

-

3

H

H

H

H

H

H

H

H

H

H

H

Spn38F

9334

K/S

+

3

           

Spn42Da

9453

A/S R/A

T/S V/A

+/-

>3

H

S

H

H

H

HS

HS

H

H

H

H

Spn42Db

9454

K/G

-

2

RHS

RHS

FHY

RHS

RSS

RSS

RSS

S

ESM

RSS

RSS

Spn42Dc

9455

M/M

-

2

H

S

H

H

H

HS

HS

H

SS

SS

SS

Spn42Dd

9456

R/A

+

3

S

S

L H S

S

SS

SS

ISR

    

Spn42De

9460

E/S

+

3

H

H

H

H

H

H

H

SL

   

Spn43Aa

12172

M/S

+

3

H

H

H

H

H

H

H

H

H

H

H

Spn43Ab

1865

-

+

3

H

S

H

H

H

H

H

H

H

H

H

Spn43Ac

1857

L/S

+

2

H

H

H

H

H

H

H

H

HL

H

H

Spn43Ad

1859

-

+

2

H

S

H

H

H

H

H

 

H

H

H

Spn47C

7722

-

-

2

H

H

H

H

H

S

S

S

S

S

S

Spn53F

10956

-

+

0

H

H

H

H

H

      

Spn55B

10913

R/M

-

1

H

H

H

H

H

H

H

H

H

H

H

Spn75F

32203

-

-

4

H

H

H

H

       

Spn76A

3801

-

+

1

S

S

S

        

Spn77Ba

6680

K/A

+

>4

H

H

H

H

H

H

H

H

HS

HS

HS

Spn77Bb

6663

-

-

3

S

          

Spn77Bc

6289

-

+

3

S

H

H

        

Spn85F

12807

-

+

1

H

H

H

S

H

H

H

H

H

H

H

Spn88Ea

18525

S/A

+

2

H

H

H

H

H

H

H

H

H

H

H

Spn88Eb

6687

S/S

+

2

HA

HA

HA

HA

       

Spn100A

1342

-

+

1

H

H

H

H

H

H

H

H

H

H

H

  1. D. melanogaster serpins are identified by cytological location and FlyBase CG number. The putative proteinase cleavage sites (P1/P1') of inhibitory serpins are indicated in single-letter amino acid code. Putative extracellular serpins are distinguished by presence of an export signal peptide. Drosophilid species are arranged from left to right in order of increasing evolutionary separation from D. melanogaster: melanogaster sub-group (simulans, sechellia, yakuba, erecta), melanogaster group (ananassae), obscura group (pseudoobscura, persimilis), willistoni group (willistoni); repleta group (mojavensis), virilis group (virilis) and the Hawaiian group (grimshawi). Serpin orthologues were identified by homology (H) or synteny (S) to D. melanogaster transcripts. Three additional orthologues identified by homology, using the complete set of Drosophilid serpin transcripts as queries, are in italic typeface (H). The putative P1/P1' residues of inhibitory serpins are conserved within orthologous transcripts except were indicated by superscripts, left of symbol for P1 substitutions (KS), right of symbol for P1'substitutions (HS). Note that the Spn42Da transcript in melanogaster has alternatively spliced 3' and 5' exons, allowing 4 different RCL sequences to be attached to the same serpin core, either with, or without, a signal peptide. Two orthologues of melanogaster Spn28F were identified in ananassae.
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BMC Genomics

ISSN: 1471-2164

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