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Table 2 Sequence conservation in serpin core and RCL between D. melanogaster and D. grimshawi

From: Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes

Serpin P1/P1'
mel
P1/P1'
gri
Alignment Score
%
Serpin core
Alignment Score
%
RCL
Spn27A K/F K/F 70 87
Spn28Dc S/G S/G 45 76
Spn31A - - 67 80
Spn42Da A/S A/S 66 69
Spn42Db K/G R/S 46 49
Spn42Dc M/M M/S 52 75
Spn43Aa M/S M/S 80 95
Spn43Ab - - 77 90
Spn43Ac L/S L/S 41 72
Spn43Ad - - 53 46
Spn47C - - 41 44
Spn55B R/M R/M 76 94
Spn77Ba K/A K/S 58 72
Spn85F - - 68 96
Spn88Ea S/A S/A 55 84
Spn100A - - 62 67
  1. The putative proteinase cleavage sites (P1/P1') of inhibitory serpins rarely change between the D. melanogaster and D. grimshawi orthologues and the RCL sequence is more strongly conserved than the serpin core. The RCL of non-inhibitory serpin-folds tends to be weakly conserved, with three exceptions, Spn31A, Spn43Ab and Spn85F. The putative RCL of the serpin-related fold, Spn100A, is conserved slightly more strongly than the remainder of the protein.