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Table 2 Selected list of genes associated with 1,25D resistance identified by expression array analysisa

From: Anti-proliferative action of vitamin D in MCF7 is still active after siRNA-VDR knock-down

Gene
symbol
Accession
Number
[GenBank:]
Gene description Chromosome
location
Expression array
(log2 ratio)
Q-PCR
Top 5 down-regulated
FAM14A NM_032036 Family with sequence similarity 14, member A 14q32.13 -2.03 -6.79
CYP24A1 NM_000782 Cytochrome P450 (Vitamin D 24-hydroxylase) 20q13 -1.20 -
PHLDA1 NM_007350 Pleckstrin homology-like domain, family A, member 1 12q15 -1.11 -3.69
ZFP276 NM_152287 Zinc finger protein 276 16q24.3 -1.02 -
- BF244871 cDNA clone IMAGE:4083158 11 -0.98 -
Top 5 up-regulated
SLITRK6 NM_032229 SLIT and NTRK-like family, member 6 13q31.1 0.98 -
BMP7 AK094784 Bone morphogenetic protein 7 20q13 0.96 -
- BG115630 cDNA clone IMAGE:4417140 4 0.95 -
DDIT4 NM_019058 DNA-damage-inducible transcript 4 10pter-q26.12 0.91 2.64
CYFIP2 NM_001037332 Cytoplasmic FMR1 interacting protein 2 5q33.3 0.89 1.98
Additionalb
FOXC1 NM_001453 Forkhead box C1 6p25 -0.80 -2.05
CRABP2 NM_001878 Cellular retinoic acid binding protein 2 1q21.3 -0.66 -2.69
ST6GALNAC5 NM_030965 GalNAc alpha-2,6-sialyltransferase V 1p31.1 -0.10 -0.39
NUAK1 NM_014840 NUAK family, SNF1-like kinase, 1 12q23.3 0.75 2.66
VDR NM_000376 Vitamin D receptor 12q13.11 - 0.13
  1. -. Not available
  2. a. Genes were identified considering FDR<0.05 as significant, with the exception of VDR due to flagging (see text for explanation)
  3. b. Additional genes selected for Q-PCR quantification