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Table 3 Selected targets

From: Steps toward broad-spectrum therapeutics: discovering virulence-associated genes present in diverse human pathogens

CI YPTB Locus Definition 50-90 Cluster ID Total non-pathogens Total pathogens Pathogen strains
0.01 2410 Magnesium transport ATPase mgtB 1035 3 8 Bme, Bma, Bp
0.03 2913 Deoxyribopyrimidine photolyase phrB 2801 0 6 Vc
0.06 2705 Putative manganese transport protein mntH 1611 3 8 Ba, Bma, Bp
0.12 3827 Outer membrane biogenesis protein 2798 0 5 -
0.13 0181 Putative protohaeme IX biogenesis protein hemY 3642 0 5 -
0.16 0756 Superoxide dismutase C sodC 1306 0 9 Bme, Cb, Ft, Vc
0.39 1340 Lysine specific permease cadR 563 2 9 Ba, Bma, Bp, Ft
0.42 0242 Glycerophosphoryl diester phosphodiesterase glpQ 2411 0 7 Bma, Bp
0.45 2699 Hypothetical protein 3924 0 7 Bma, Bp
0.76 1424 Hypothetical protein 1031 3 9 Bma, Bp, Ft, Vc
0.87 3166 Thiol:disulphide interchange protein dscB 3283 0 5 -
2.38 0188 Frataxin-like protein cyaY 2139 2 6 Vc
3.15 3505 Stringent starvation protein sspB 1207 3 7 Cb, Vc
ND 1167 Phosphate starvation protein 3911 0 6 -
ND 1251 Ecotin 3380 0 6 -
ND 2026 MviN-like protein 1296 3 9 Bma, Bp, Cb
ND 2995 Putative surface antigen 2296 2 7 Vc
  1. Virulence-associated genes identified by computational methods and selected for experimental screening. These targets have been ranked by their competitive index (CI) value in Y. pseudotuberculosis. The CI value shown is the mean of the CI calculated from 3 spleens individually plated in triplicate. The top six candidates are deemed virulence-related by our experimental criteria. Hits to pathogens include all five members of the Enterobacteriaceae (Ec, Se, Sf, St, Yp) plus the additional strains listed using abbreviations from Table 1.
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