From: Information-theoretic gene-gene and gene-environment interaction analysis of quantitative traits
Locus | Chr | SNP # | Phenotype | Effects |
---|---|---|---|---|
DR | 6 | 152-155 | RA | Affects risk of RA |
A | 16 | 30-31 | RA | Controls effect of DR on RA risk |
B | 8 | 442 | RA | Controls effect of smoking on RA risk |
C | 6 | 152-155 | RA | Increases RA risk only in women |
D | 6 | 161-162 | RA | Rare allele increases RA risk 5-fold |
E | 18 | 268-269 | RA, Anti-CCP | Affects DR on anti-CCP and increases RA risk |
F | 11 | 387-389 | IgM | QTL for IgM |
G | 9 | 185-186 | Severity | 25% QTL for severity |
H | 9 | 192-193 | Severity | 25% QTL for severity |
Age | - | Â | RA | Affects RA risk through smoking and sex ratio |
Sex | - | Â | RA | Affects RA risk with Locus C |
Smoking | - | Â | RA, IgM | Affects RA risk with Locus B and IgM. |