Skip to main content

Table 1 Effects of major trait loci and covariates in the GAW15 data set.

From: Information-theoretic gene-gene and gene-environment interaction analysis of quantitative traits

Locus

Chr

SNP #

Phenotype

Effects

DR

6

152-155

RA

Affects risk of RA

A

16

30-31

RA

Controls effect of DR on RA risk

B

8

442

RA

Controls effect of smoking on RA risk

C

6

152-155

RA

Increases RA risk only in women

D

6

161-162

RA

Rare allele increases RA risk 5-fold

E

18

268-269

RA, Anti-CCP

Affects DR on anti-CCP and increases RA risk

F

11

387-389

IgM

QTL for IgM

G

9

185-186

Severity

25% QTL for severity

H

9

192-193

Severity

25% QTL for severity

Age

-

 

RA

Affects RA risk through smoking and sex ratio

Sex

-

 

RA

Affects RA risk with Locus C

Smoking

-

 

RA, IgM

Affects RA risk with Locus B and IgM.

  1. The loci associated with IgM and Anti-CCP QT are shown in bold.