Genome and gene alterations by insertions and deletions in the evolution of human and chimpanzee chromosome 22

BMC Genomics

Table 1 Indels Observed in the Human and Chimpanzee Chromosome 22 Comparison

Type	Total bp	bp %	# Events	# Events %
STRs	614,359	1.8	2572	41.0
Known Repetitive DNA	640,133	1.9	2277	36.2
SINE/Alu	355,124	(1.07)	1593
Line/L1	138,880	(0.4)	247
SINE/Mir	18,767	(0.05)	69
LTR/ERV1	60,003	(0.18)	232
Other	67,359	(0.2)	136
Indels	82,661	0.25	1429	22.8
Insertion	34,868	(0.11)	746
Deletion	47,793	(0.14)	683
TOTAL	1,760,410	5.3	6278	100

A total of 6,278 indels of size ≥ 10 bp were seen in comparison of human and chimpanzee chromosomes 22. Most of these were either in Short Tandem Repeats (STRs) or Known Repetitive DNAs, where the major types are shown. The remaining indels (0.25%) were classified as insertions or deletions relative to the human sequence. Another 0.25% of the indels were 2–9 bp (19,932, totalling 76,486 bp). In addition, 346,771 Single Nucleotide Differences were seen in the UCSC alignment totalling 1.0% of the bases compared.

ISSN: 1471-2164