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Figure 1 | BMC Genomics

Figure 1

From: Correlation of microsynteny conservation and disease gene distribution in mammalian genomes

Figure 1

The correlation between microsynteny and density of orthologs of disease-related genes on mouse autosomes. The relationship between conserved microsynteny (black) and density of mouse genes orthologous to human disease-related genes (blue) is shown for all mouse autosomes. Percentage of genes with conserved microsynteny and those with disease-related orthologs are calculated for a 20 Mb sliding window, offset by steps of 5 Mb. At each position the Z-score is plotted at the center of the sliding window. Pearson's correlation coefficient and P-values for the analysis of co-localization of conserved microsyteny and disease gene orthologs are given for each chromosome. The results of a randomization of the disease genes (red) demonstrate that there is no correlation between microsynteny (black) and random assignment of gene status.

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